Community Research and Development Information Service - CORDIS

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Solving an evolutionary jigsaw puzzle: A next-generation genomics approach to trace the origins of the eukaryotic cell
ID: 310039
Start date: 2012-11-01, End date: 2017-10-31
The origin of the eukaryotic cell represents an enigmatic yet dramatically incomplete evolutionary puzzle. The few pieces of this puzzle that we have managed to identify thus far indicate that the eukaryotic cell most probably emerged via a fusion of an archaeal and an alphap...
Programme: FP7-IDEAS-ERC
Record Number: 105594
Last updated on: 2017-10-06
Microbial opsins for mammalian vision: Optogenetics in the retina
ID: 309776
Start date: 2012-12-01, End date: 2018-11-30
The retina – a thin sheet of neural tissue in the back of the eye – is a sophisticated image processor which analyzes the incoming light pattern through a set of separate spatio-temporal channels and relays this information to the brain. The loss of the visual sense due to re...
Programme: FP7-IDEAS-ERC
Record Number: 106060
Last updated on: 2017-10-06
Protection against reactive oxygen species in neurodegeneration
ID: 311394
Start date: 2013-02-01, End date: 2018-05-31
Oxidative stress (OS) is implicated in the pathogenesis of some of the most devastating neurological diseases. Therefore, identification of pathways that counteract oxidative damage may lead to therapeutic strategies applicable to a wide range of disorders. I have recently id...
Programme: FP7-IDEAS-ERC
Record Number: 106704
Last updated on: 2017-09-24
Proliferation and Migration under External Constraints
ID: 311205
Start date: 2013-01-01, End date: 2018-06-30
Cell proliferation lies at the heart of the threat posed by tumours. It involves cellular growth, division and migration. The tissue surrounding a tumor physically limits its proliferation, which implies that cells that are able to produce effective tumour growth, as well as ...
Programme: FP7-IDEAS-ERC
Record Number: 106353
Last updated on: 2017-09-24
Anatomical and Functional Dissection of Neural Circuits in the Zebrafish Optic Tectum
ID: 311159
Start date: 2013-01-01, End date: 2018-06-30
The optic tectum has emerged as a tractable visuomotor transformer, in which anatomical and functional studies can allow a better understanding of how behavior is controlled by neuronal circuits. We plan to examine the formation and function of the visual system in zebrafish ...
Programme: FP7-IDEAS-ERC
Record Number: 106304
Last updated on: 2017-09-24
Molecular Mechanisms of GABAergic synapse formation: spatial segregation in cortical inhibitory inputs
ID: 310021
Start date: 2013-01-01, End date: 2018-06-30
Neuronal circuitries underlying the function of the mammalian cerebral cortex collectively constitute one of the most complex biological systems. As such, unraveling the mechanisms that control their development represents one of the most challenging questions in Science. Und...
Programme: FP7-IDEAS-ERC
Record Number: 105616
Last updated on: 2017-09-24
Endosomal dependent transport to the unique secretory organelles of apicomplexan parasites
ID: 309255
Start date: 2013-02-01, End date: 2019-01-31
Apicomplexan parasites invade the host cell in an active process that involves gliding motility, formation and movement through the moving junction (MJ) and establishment of a prasitophorous vacuole (PV) around the parasite. In order to invade the host cell they employ an ars...
Programme: FP7-IDEAS-ERC
Record Number: 105401
Last updated on: 2017-09-10
Mechanisms Underlying Treatment Responses in Psychosis
ID: 311686
Start date: 2013-03-01, End date: 2018-11-30
Psychotic symptoms (hallucinations and delusions) have been associated with a striatal hyperdopaminergic state. Less explored, but also implicated are functional abnormalities in cognitive control, particularly in the prefrontal cortex; and a functional and structural disconn...
Programme: FP7-IDEAS-ERC
Record Number: 106740
Last updated on: 2017-09-03
Therapies for inborn errors of metabolism
ID: 311596
Start date: 2012-11-01, End date: 2018-10-31
We discovered that phenylbutyrate, prevents both in vitro and in vivo the inactivation by phosphorylation of the branched chain ketoacid dehydrogenase complex (BCKDC) and pyruvate dehydrogenase complex (PDHC). We show that phenylbutyrate is effective for treatment of maple sy...
Programme: FP7-IDEAS-ERC
Record Number: 105793
Last updated on: 2017-09-03
NutrImmune: Nutrient-controlled molecular pathways instructing development and function of mucosa-associated innate lymphocytes
ID: 311377
Start date: 2013-03-01, End date: 2018-02-28
The last decade has witnessed an explosion of research into the molecular networks ensuring maintenance of a mutualistic relationship between microbes and host cell networks at mucosal surfaces. Failure of such homeostatic or adaptive programs lead to susceptibility to intest...
Programme: FP7-IDEAS-ERC
Record Number: 107185
Last updated on: 2017-09-03
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List retrieved on: 2017-11-22
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