Community Research and Development Information Service - CORDIS

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NutrImmune: Nutrient-controlled molecular pathways instructing development and function of mucosa-associated innate lymphocytes
ID: 311377
Start date: 2013-03-01, End date: 2018-02-28
The last decade has witnessed an explosion of research into the molecular networks ensuring maintenance of a mutualistic relationship between microbes and host cell networks at mucosal surfaces. Failure of such homeostatic or adaptive programs lead to susceptibility to intest...
Programme: FP7-IDEAS-ERC
Record Number: 107185
Last updated on: 2017-09-03
Improved Diagnosis and Management of Heart Disease by 4D Blood Flow Assessment
ID: 310612
Start date: 2013-01-01, End date: 2017-12-31
The primary purpose of the cardiovascular system is to drive, control and maintain blood flow to all parts of the body. Despite the primacy of flow, cardiac diagnostics still rely almost exclusively on tools focused on morphological assessment. The objective of the HEART4FLOW...
Programme: FP7-IDEAS-ERC
Record Number: 106001
Last updated on: 2017-09-03
Circuit mechanics of emotions in the limbic system
ID: 311701
Start date: 2013-01-01, End date: 2018-06-30
Numerous studies established the role of the limbic system in fear and reward: it integrates sensory information, encodes emotional states and instructs other brain centers to regulate physiology and behavior. The limbic system, however, consists of many distinct and highly i...
Programme: FP7-IDEAS-ERC
Record Number: 105747
Last updated on: 2017-08-27
Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers
ID: 310917
Start date: 2013-02-01, End date: 2019-01-31
Lymphoid cancers are among the most common human malignancies and characteristically harbour genomic aberrations. Although databases will soon be flooded with genome sequences from thousands of tumours, interpretation and validation of these data is limited by the genetic var...
Programme: FP7-IDEAS-ERC
Record Number: 106163
Last updated on: 2017-08-27
Dissecting the genetic basis of divergent and convergent evolution: From individuals to species radiations
ID: 310482
Start date: 2013-02-01, End date: 2019-01-31
Advances in genomics offer new opportunities for identifying loci that behave unusually against a background of neutral variation. Detecting divergent sites among related individuals and taxa can shed light on the process of adaptive divergence, from non-random mating to the ...
Programme: FP7-IDEAS-ERC
Record Number: 106425
Last updated on: 2017-08-27
Dosage sensitive genes in evolution and disease
ID: 309834
Start date: 2013-01-01, End date: 2018-12-31
Evolutionary change of gene copy number through gene duplication is a relatively pervasive phenomenon in eukaryotic genomes. However, for a subset of genes such changes are deleterious because they result in imbalances in the cell. Such dosage-sensitive genes have been increa...
Programme: FP7-IDEAS-ERC
Record Number: 104726
Last updated on: 2017-08-27
Understanding the development and function of cerebral cortex folding
ID: 309633
Start date: 2013-01-01, End date: 2018-06-30
The mammalian cerebral cortex was subject to a dramatic expansion in surface area during evolution. This process is recapitulated during development and is accompanied by folding of the cortical sheet, which allows fitting a large cortical surface within a limited cranial vol...
Programme: FP7-IDEAS-ERC
Record Number: 105577
Last updated on: 2017-08-27
Dissection of centromeric chromatin and components: A biosynthetic approach
ID: 311674
Start date: 2013-02-01, End date: 2019-01-31
The centromere is one of the most important chromosomal elements. It is required for proper chromosome segregation in mitosis and meiosis and readily recognizable as the primary constriction of mitotic chromosomes. Proper centromere function is essential to ensure genome stab...
Programme: FP7-IDEAS-ERC
Record Number: 106164
Last updated on: 2017-08-22
Bacterial effector secretion: Function and Architecture of the Type 3 Secretion System
ID: 311374
Start date: 2013-01-01, End date: 2017-12-31
Bacterial pathogens secrete effector proteins to manipulate host cells during infection. In Gram-negative bacteria the conserved type 3 secretion system (T3SS) delivers effector proteins to the host cell in a spatiotemporal manner. Although major T3SS constituting components ...
Programme: FP7-IDEAS-ERC
Record Number: 105833
Last updated on: 2017-08-13
The Structure and Assembly of Membrane Proteins in Native Membranes studied by AFM
ID: 310080
Start date: 2013-01-01, End date: 2017-12-31
One of the key characteristics of life is the existence of boundaries that delineate the organism from its environment. The boundary membrane structure that defines all cells is called the plasma membrane. Membranes are constituted of a large variety of lipids and membrane pr...
Programme: FP7-IDEAS-ERC
Record Number: 105216
Last updated on: 2017-08-13
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List retrieved on: 2017-11-25
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