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The Molecular Communication Mechanism of Motor Neuron Survival and Synapse Maintenance
ID: 309377
Start date: 2013-02-01, End date: 2019-01-31
In order to survive and maintain normal function, the cell depends on a dynamic system of spatial specificity and fidelity of signaling pathways that can respond to both internal and external changes over space and time. This cell-cell communication is mediated by ligand-rece...
Programme: FP7-IDEAS-ERC
Record Number: 106160
Last updated on: 2017-07-02
Fine Tuning the Final Common Pathway: Molecular Determinants of Motor Unit Development and Plasticity
ID: 311710
Start date: 2012-11-01, End date: 2017-10-31
Motor neurons (MNs) constitute the final common pathway in the generation of behaviors by linking the CNS with the movement apparatus. Herein, MNs diversify into fast, intermediate and slow types whose properties are tuned to the speed, force and endurance of the muscle fiber...
Programme: FP7-IDEAS-ERC
Record Number: 105218
Last updated on: 2017-06-26
Fitness drivers in long-distance migrants: the interacting roles of physiology, social biology, ecological and physical environments
ID: 310820
Start date: 2013-02-01, End date: 2019-01-31
Long distance migration in birds is among the most dramatic and exciting phenomena in nature. However despite many years of study, there are still huge gaps in our understanding of how this behaviour shapes individual ecology and influences population processes. For example, ...
Programme: FP7-IDEAS-ERC
Record Number: 106595
Last updated on: 2017-06-26
SUMOrice: Exploiting an emerging protein modification system, SUMOylation to boost rice yield during drought and salt stress
ID: 310235
Start date: 2013-04-01, End date: 2019-03-31
"To feed 9 billion people by 2050 is an unprecedented challenge. Rice is the food source for the majority of the world's population but also a model for cereals. Drought and related high salinity during essential periods of plant growth affects nearly all crops including the ...
Programme: FP7-IDEAS-ERC
Record Number: 107495
Last updated on: 2017-06-21
Reverse engineering the vertebrate molecular machinery for magnetic biomineralisation
ID: 311552
Start date: 2013-01-01, End date: 2017-12-31
In order to understand distributed biological networks and invent effective molecular therapies, we need to be able to image and control molecular processes across entire live organisms. Although an arsenal of genetically encoded fluorescent sensors and light-activated protei...
Programme: FP7-IDEAS-ERC
Record Number: 106439
Last updated on: 2017-06-12
Towards a mechanistic understanding of mRNA localization
ID: 310957
Start date: 2013-01-01, End date: 2018-12-31
The localization of mRNAs has been increasingly recognized as a prominent mode of regulation of gene expression in eukaryotes. Localized RNAs can have crucial roles during animal development, in the maintenance of cell polarity and in nervous system function. Studies of RNA l...
Programme: FP7-IDEAS-ERC
Record Number: 105717
Last updated on: 2017-06-12
Biochemical reconstitution of DNA repair reactions on physiological chromatin substrates
ID: 311336
Start date: 2013-01-01, End date: 2018-12-31
For cells and organisms to survive and propagate, they must accurately pass on their genetic information to the next generation. Errors in this process may arise from spontaneous mistakes in normal cellular metabolism, or from exposure to external agents, such as chemical mut...
Programme: FP7-IDEAS-ERC
Record Number: 105906
Last updated on: 2017-06-05
Coevolution of bacteria and conjugative plasmids
ID: 311490
Start date: 2013-02-01, End date: 2018-01-31
Horizontal gene transfer (HGT) is a fundamental process of bacterial evolution, accelerating adaptation to novel environments and providing access to new ecological niches. However, two of the three mechanisms of HGT, transduction and conjugation, both rely on semi-autonomous...
Programme: FP7-IDEAS-ERC
Record Number: 105951
Last updated on: 2017-05-22
Genetic and Epigenetic Determinants of Paget's Disease of bone
ID: 311723
Start date: 2012-10-01, End date: 2018-03-31
Paget’s disease of bone (PDB) is a common disease characterised by focal areas of increased bone turnover leading to symptoms of bone pain, deformity, osteoarthritis and other complications. Genetic factors play an important role in PDB and mutations in SQSTM1 gene are respon...
Programme: FP7-IDEAS-ERC
Record Number: 105219
Last updated on: 2017-05-22
New biomarkers for Alzheimer’s & Parkinson’s diseases - key tools for early diagnosis and drug development
ID: 311292
Start date: 2013-06-01, End date: 2018-05-31
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are common in elderly and the prevalence of these is increasing. AD and PD have distinct pathogenesis, which precede the overt clinical symptoms by 10-15 years, opening a window for early diagnosis and treatment. New disea...
Programme: FP7-IDEAS-ERC
Record Number: 107847
Last updated on: 2017-05-22
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List retrieved on: 2017-11-21
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