Community Research and Development Information Service - CORDIS

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In vivo pathogen proteome profiling using selected reaction monitoring
ID: 309831
Start date: 2013-05-01, End date: 2018-04-30
Bacterial infections represent a major and global health problem, which is further aggravated by the rapid and ongoing increase in antibiotic resistance. The limited success in the development of targeted therapies for particular invasive strains can be attributed to our limi...
Programme: FP7-IDEAS-ERC
Record Number: 107911
Last updated on: 2017-05-22
IN VIVO REPROGRAMMING: A NOVEL ROUTE TO BRAIN REPAIR
ID: 309712
Start date: 2013-03-01, End date: 2018-02-28
Recent progress on direct re-programming into functional neurons provides a new approach towards cell-based therapy for neurodegenerative disorders. The induced neurons (iNs) are a novel type of cell resulting from rapid and remarkable conversion of somatic cells into subtype...
Programme: FP7-IDEAS-ERC
Record Number: 107399
Last updated on: 2017-05-22
Exploring the tumor as a communicating organ
ID: 309322
Start date: 2013-03-01, End date: 2018-02-28
The failure to bring about major advances in cancer care over the past decades points to the need for a revolution in our view of cancer as a disease caused by a lack of growth control in malignant cells. We propose that a tumor should be considered a communicating organ made...
Programme: FP7-IDEAS-ERC
Record Number: 107397
Last updated on: 2017-05-22
Mechanistic dissection of myofibrillogenesis and sarcomerogenesis in insect muscle
ID: 310939
Start date: 2013-02-01, End date: 2019-01-31
Higher animals employ a complex muscle network for their daily movements. Proper execution of movements requires individual muscles to form at the correct positions, connect to proper tendons and produce sufficient force. Muscle development is a multi-step process: myoblasts ...
Programme: FP7-IDEAS-ERC
Record Number: 105666
Last updated on: 2017-05-08
Closing in on missing heritability and immune dysregulation in macular degeneration
ID: 310644
Start date: 2013-01-01, End date: 2017-12-31
Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the Western world. AMD has a strong genetic component, and it has been estimated that 50% of the heritability of AMD is explained by common variants in the complement system. Currentl...
Programme: FP7-IDEAS-ERC
Record Number: 106206
Last updated on: 2017-05-08
The interaction landscape between microbial colonization and functional genome of the host: a systems biology approach in fungal infections
ID: 310372
Start date: 2013-01-01, End date: 2017-12-31
Fungi such as Candida albicans are ubiquitous colonizers of human skin and mucosa. Fungal pathogens invade the host when host defence is diminished, and the combination of fungal and bacterial colonization modulates mucosal and systemic immune responses. Little is known of th...
Programme: FP7-IDEAS-ERC
Record Number: 105950
Last updated on: 2017-05-08
analysis of postmitotic chromatin decondensation
ID: 309528
Start date: 2013-03-01, End date: 2018-02-28
Chromatin undergoes fascinating structural and functional changes during the metazoan cell cycle. It massively condenses at the beginning of mitosis with a degree of compaction up to fiftyfold higher than in interphase. At the end of mitosis, mitotic chromosomes decondense to...
Programme: FP7-IDEAS-ERC
Record Number: 106861
Last updated on: 2017-05-08
Regulation of gene expression and cell fate by DNA (hydroxy)methylation
ID: 309384
Start date: 2013-10-01, End date: 2018-09-30
(Hydroxy)methylation of cytosine residues in eukaryotic DNA represents a major means to regulate gene expression during development. These modifications are considered to be epigenetic marks, since they have a profound impact on phenotype, but are inherited from mother to dau...
Programme: FP7-IDEAS-ERC
Record Number: 105899
Last updated on: 2017-05-08
Influence of nutrient starvation on corals' susceptibility to bleaching
ID: 311179
Start date: 2012-11-01, End date: 2017-10-31
INCORALS will establish a novel conceptual model that introduces a transition of symbiotic algae from a nutrient limited to a nutrient starved state as a process that renders reef building corals more susceptible to heat stress. Elevated temperatures have been identified as t...
Programme: FP7-IDEAS-ERC
Record Number: 105179
Last updated on: 2017-04-24
The role of pericytes in central nervous system scarring and fibrosis
ID: 310938
Start date: 2013-02-01, End date: 2018-01-31
Damage to the central nervous system (CNS) often leads to persistent functional deficits, causing great individual suffering and enormous cost to society. The manifestation of these deficits is believed to be associated with the scar tissue that forms locally at lesions, caus...
Programme: FP7-IDEAS-ERC
Record Number: 106180
Last updated on: 2017-04-10
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List retrieved on: 2017-11-23
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