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Detailed binding scheme and structural determination of the 14-3-3ζ in complex with a double phosphorylated  human tyrosine hydroxylase 1
ID: 618460
Start date: 2013-10-01, End date: 2017-09-30
14-3-3 proteins, found in all eukaryotic cells, are known to be important in cell-cycle regulation, apoptosis, and regulation of gene expression. They are also associated with oncogenic and neurodegenerative amyloid diseases. 14-3-3 proteins are active as homo- or heterodimer...
Programme: FP7-PEOPLE
Record Number: 110122
Last updated on: 2017-05-22
Structure, maturation and cell entry mechanisms of ranavirus virions
ID: 618111
Start date: 2013-09-01, End date: 2017-08-31
The long-term goal of this proposal is to understand the molecular mechanisms of the replication cycle of nucleocytoplasmic large DNA viruses that attracted attention after the discovery of the giant Mimivirus a decade ago. Here, we focus on ranaviruses from the family Iridov...
Programme: FP7-PEOPLE
Record Number: 109553
Last updated on: 2017-05-22
Supply-rate depression as endogenous anti-epileptic mechanism
ID: 322013
Start date: 2012-09-01, End date: 2017-08-24
Epilepsy is a prevalent neurological disorder affecting more than 1 % of all people, with the estimated number of 900,000 children and adolescents suffering from active epilepsy in Europe. Most current drugs targeting this disease have important adverse side-effects. An ideal...
Programme: FP7-PEOPLE
Record Number: 104640
Last updated on: 2017-05-22
Elucidating the role of SALMs in the regulation of synapses and NMDA receptors
ID: 276827
Start date: 2011-07-01, End date: 2015-06-30
Cell adhesion molecules (CAMs) mediate many critical processes in the mammalian brain, including formation and maturation of synapses. CAMs have been implicated in cognitive diseases, such as autism and schizophrenia, as candidate genes. These studies highlight the importance...
Programme: FP7-PEOPLE
Record Number: 99557
Last updated on: 2017-05-22
Homotopy algebras in homotopy theory and higher category theory
ID: 256341
Start date: 2011-09-01, End date: 2015-08-31
We will study in this project exciting new interactions and applications between two fundamental modern research areas of mathematics, homotopy theory and higher category theory. These areas of mathematics are used in applied sciences. For instance, homotopy theory is used in...
Programme: FP7-PEOPLE
Record Number: 95727
Last updated on: 2017-05-22
Role of Epoxyeicosatrienoic Acids in the Regulation of Blood Pressure, Renal Hemodynamics and Sodium Excretion in Renovascular Model of Hypertension
ID: 247847
Start date: 2009-10-01, End date: 2016-09-30
Cytochrome P450 (CYP) metabolites are more frequently recognized as important regulators of cardiovascular and renal functions. CYP epoxygenases produce epoxyeicosatrienoic acids (EETs) that exhibit vasodilatory and natriuretic properties. EETs are degraded by the enzyme solu...
Programme: FP7-PEOPLE
Record Number: 94024
Last updated on: 2017-05-22
Biologically Active Organic Compounds Interacting with Adenine-binding Proteins
ID: 230936
Start date: 2010-01-01, End date: 2015-05-01
Proposed are rational design and synthesis of novel patentable organic compounds that are envisioned to be active against various adenine-binding proteins, e.g. kinases. The structures contain heterocyclic cores relatively unknown in the literature and will mimic interations ...
Programme: FP7-PEOPLE
Record Number: 93367
Last updated on: 2017-05-22
Trait diversity: assemblage of communities and their feedbacks to Ecosystem Multifunctionality
ID: 626392
Start date: 2014-12-01, End date: 2016-11-30
In order to deal with the generalized losses in biodiversity and its adverse effect on the provision of ecosystem, services, it is critical to understand the mechanisms behind the assemblage and coexistence of species, including the relative effect of environmental and land-u...
Programme: FP7-PEOPLE
Record Number: 188007
Last updated on: 2017-04-17
Environmentally Controlled Polymorphism of non-B DNA structures
ID: 322104
Start date: 2012-10-01, End date: 2016-09-30
Repetitive blocks of guanine- and cytosine-rich sequences, such as those occurring in centromeric and telomeric DNA regions and promoter regions of protein coding genes, have ability to form G- and C-quadruplex structures, respectively. These non-B DNA structures are involved...
Programme: FP7-PEOPLE
Record Number: 104905
Last updated on: 2017-03-22
Small-Molecule Probes of Neuronal Differentiation
ID: 322001
Start date: 2012-11-01, End date: 2016-10-31
Proposal presented herein combines methods of synthetic organic chemistry, cellular neurobiology, and chemical biology to study processes involved in neuronal differentiation. The primary objective of the project is to discover, characterize, and make broadly available high-q...
Programme: FP7-PEOPLE
Record Number: 105570
Last updated on: 2017-03-22
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List retrieved on: 2017-05-23
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