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The NGF system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain
ID: 603191
Start date: 2014-04-01, End date: 2017-12-31
So far, there are no effective treatments for neuropathic pain (NP), and current treatments suffer from serious unwanted side effects. The NGF ligand-receptor system has recently emerged as a novel target for NP of great therapeutic potential, a master regulator, controlling ...
Programme: FP7-HEALTH
Record Number: 185456
Last updated on: 2017-10-06
Mechanisms and Treatment of Migraine and its Chronification
ID: 602633
Start date: 2014-02-01, End date: 2017-01-31
Migraine is a common brain disorder, typically characterised by recurring, incapacitating attacks of 1-3 days of severe headache, autonomic dysfunction, and sometimes aura symptoms. The disease affects 15% of all European citizens including children, ranks among the WHO top 1...
Programme: FP7-HEALTH
Record Number: 109470
Last updated on: 2017-10-06
King of hearts, joints and lungs; periodontal pathogens as etiologic factor in RA, CVD and COPD and their impact on treatment strategies
ID: 306029
Start date: 2013-04-01, End date: 2017-03-31
Extensive clinical and epidemiological data clearly shows that chronic periodontal disease (PD), the most prevalent infectious inflammatory disease of mankind, is strongly linked to systemic inflammatory diseases such as cardiovascular diseases (CVD) , rheumatoid arthritis (R...
Programme: FP7-HEALTH
Record Number: 106057
Last updated on: 2017-10-06
Development and clinical trials of a new Software ENgine for the Assessment & Optimization of drug and non-drug Therapy in Older peRsons
ID: 305930
Start date: 2012-10-01, End date: 2018-06-30
The European population of older people with multiple chronic diseases (multimorbidity) is increasing steadily in tandem with the rising population of people aged ≥ 65 years. Older multimorbid people are at high risk of polypharmacy (PP), inappropriate prescribing (IP), adver...
Programme: FP7-HEALTH
Record Number: 105397
Last updated on: 2017-09-24
Clinical development of a VAR2CSA-based placental malaria vaccine
ID: 304815
Start date: 2013-03-01, End date: 2017-02-28
Placental malaria, a special form of malaria targeting pregnant women, causes the death of 200,000 infants and 10,000 pregnant women each year. Placental malaria has no sustainable cure. The overall success criterion of the proposed project is to enable the manufacture of a v...
Programme: FP7-HEALTH
Record Number: 106907
Last updated on: 2017-09-10
CAncer Risk and INsulin analoGues
ID: 282526
Start date: 2011-11-01, End date: 2015-10-31
Several studies have linked the use of insulins to the risk of cancer, and it is certainly plausible that as a growth factor, exposure to administered insulin could stimulate neoplastic growth. However, the meta-analyses of randomized clinical trials comparing different insul...
Programme: FP7-HEALTH
Record Number: 100436
Last updated on: 2017-09-10
Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression
ID: 279228
Start date: 2012-01-01, End date: 2015-12-31
Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health...
Programme: FP7-HEALTH
Record Number: 101811
Last updated on: 2017-09-10
A European Platform for Translational Cancer Research
ID: 260791
Start date: 2011-01-01, End date: 2016-12-31
Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer r...
Programme: FP7-HEALTH
Record Number: 97701
Last updated on: 2017-09-10
Predicting individual response and resistance to VEGFR/mTOR pathway therapeutic intervention using biomarkers discovered through tumour functional genomics
ID: 259303
Start date: 2011-01-01, End date: 2014-12-31
The strategic development of accurate biomarkers to predict response to therapy in cancer medicine will enhance clinical outcome and reduce the health economic impact of drug resistant disease. The PREDICT consortium will identify and validate predictive biomarkers for two dr...
Programme: FP7-HEALTH
Record Number: 97661
Last updated on: 2017-09-10
International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research
ID: 278514
Start date: 2011-10-01, End date: 2017-09-30
Though survival of children with acute lymphoblastic leukaemia (ALL) has improved, relapse remains a leading cause of mortality in childhood cancer. Given the rarity of the disease, only a large international cooperative group can recruit sufficient patients for prospective s...
Programme: FP7-HEALTH
Record Number: 102104
Last updated on: 2017-09-03
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List retrieved on: 2017-10-18
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