Community Research and Development Information Service - CORDIS

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Metformin for treatment of polycystic ovary syndrome in children
ID: 602243
Start date: 2013-10-01, End date: 2017-03-31
PCOS, a common disorder affecting 5-10% of women of reproductive age is characterized by cystic ovarian morphology, androgen excess, and/or irregular periods and emerges during or shortly after puberty. The common off-label use of metformin for treating PCOS in children appea...
Programme: FP7-HEALTH
Record Number: 110171
Last updated on: 2017-07-12
Clinical Development of Nitisinone for Alkaptonuria
ID: 304985
Start date: 2012-11-01, End date: 2018-04-30
DevelopAKUre is a proposal to fund the clinical development of an orphan designated drug, nitisinone, for the treatment of a rare Mendelian disease, Alkaptonuria (AKU). AKU is a genetic deficiency of homogentisic acid dioxygenase, causing high levels of homogentisic acid (HGA...
Programme: FP7-HEALTH
Record Number: 106157
Last updated on: 2017-07-12
Integrated research on DEvelopmental determinants of Aging and Longevity
ID: 259679
Start date: 2011-02-01, End date: 2016-01-31
IDEAL will obtain insight into the role of early life conditions affecting late-life health, disease and aging, and the role of epigenetic regulation therein. IDEAL will identify the determinants and targets of this epigenetic regulation utilizing a resource of unique human c...
Programme: FP7-HEALTH
Record Number: 98424
Last updated on: 2017-07-12
Metastatic tumours facilitated by hypoxic tumour micro-environments
ID: 222741
Start date: 2009-02-01, End date: 2014-07-31
Recent research suggests that the hypoxic micro-environment of tumours is one of the major drivers of metastatic spread of cancer. Furthermore, hypoxic tumour micro-environments may result in treatment resistance of cancer cells, therefore causing a double effect of reducing ...
Programme: FP7-HEALTH
Record Number: 91061
Last updated on: 2017-07-12
The NGF system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain
ID: 603191
Start date: 2014-04-01, End date: 2017-12-31
So far, there are no effective treatments for neuropathic pain (NP), and current treatments suffer from serious unwanted side effects. The NGF ligand-receptor system has recently emerged as a novel target for NP of great therapeutic potential, a master regulator, controlling ...
Programme: FP7-HEALTH
Record Number: 185456
Last updated on: 2017-06-26
Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope
ID: 602299
Start date: 2013-10-01, End date: 2018-09-30
An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading...
Programme: FP7-HEALTH
Record Number: 110067
Last updated on: 2017-06-26
Effective Perinatal Intensive Care in Europe: translating knowledge into evidence based practice
ID: 259882
Start date: 2011-01-01, End date: 2015-12-31
Context: Very preterm infants face high risks of mortality and long-term neuro-developmental impairment. Rates of mortality and morbidity vary by a factor greater than two between European regions. This project’s overriding aim is to improve these infants’ survival and long-t...
Programme: FP7-HEALTH
Record Number: 97698
Last updated on: 2017-06-12
Tools for the Detection of  Novel Glyco-biomarkers
ID: 259869
Start date: 2011-01-01, End date: 2015-12-31
Glycosylation patterns on glycoproteins and glycolipids are involved in the regulation of inter- and intracellular recognition events and alteration of such glycosylation has been observed in many diseases, notably in a variety of cancers. We propose that a systematic, large ...
Programme: FP7-HEALTH
Record Number: 97678
Last updated on: 2017-06-12
Systems Biology of Stem Cells and Reprogramming
ID: 242129
Start date: 2010-06-01, End date: 2015-11-30
Stem cells are central to emerging concepts in health, medicine and therapy. The realization that specific cell reservoirs retain multipotency for tissue establishment and replenishment has implications for both the emerging field of regenerative therapy and the long standing...
Programme: FP7-HEALTH
Record Number: 94539
Last updated on: 2017-06-05
Discovery and preclinical development of new generation tuberculosis vaccines
ID: 241745
Start date: 2010-01-01, End date: 2014-02-28
With 14.4 million prevalent cases and 1.7 million deaths tuberculosis (TB) remains one of the most serious infectious diseases to date. An estimated 2 billion people are believed to be infected with Mycobacterium tuberculosis and at risk of developing disease. Multi- and exte...
Programme: FP7-HEALTH
Record Number: 93343
Last updated on: 2017-06-05
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List retrieved on: 2017-07-22
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