Community Research and Development Information Service - CORDIS

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MEsenchymal stem cells to Reduce Liver INflammation
ID: 602363
Start date: 2014-02-01, End date: 2019-01-31
Prevalence of liver disease is c6% (29 million people) in the EU with mortality rates from chronic liver diseases estimated at 14.3 per 100.000 in the EU-25 in 2004. Most liver diseases have a significant inflammatory component that underpins liver damage and fibrogenesis, ye...
Programme: FP7-HEALTH
Record Number: 109461
Last updated on: 2017-07-16
Rational Therapy for Breast Cancer: Individualized Treatment for Difficult-to-Treat Breast Cancer Subtypes
ID: 258967
Start date: 2011-01-01, End date: 2018-06-30
Cancer genotyping has identified a number of correlations between mutations in specific genes and responses to targeted anti-cancer drugs, with many mutations occurring in kinases or downstream signaling components. While there are several ongoing large-scale genome re-sequen...
Programme: FP7-HEALTH
Record Number: 97660
Last updated on: 2017-07-16
Multidisciplinary Approaches to Translational Research In Conduct Syndromes
ID: 603016
Start date: 2014-03-01, End date: 2019-02-28
Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on th...
Programme: FP7-HEALTH
Record Number: 111344
Last updated on: 2017-07-12
Metformin for treatment of polycystic ovary syndrome in children
ID: 602243
Start date: 2013-10-01, End date: 2017-03-31
PCOS, a common disorder affecting 5-10% of women of reproductive age is characterized by cystic ovarian morphology, androgen excess, and/or irregular periods and emerges during or shortly after puberty. The common off-label use of metformin for treating PCOS in children appea...
Programme: FP7-HEALTH
Record Number: 110171
Last updated on: 2017-07-12
Clinical Development of Nitisinone for Alkaptonuria
ID: 304985
Start date: 2012-11-01, End date: 2018-04-30
DevelopAKUre is a proposal to fund the clinical development of an orphan designated drug, nitisinone, for the treatment of a rare Mendelian disease, Alkaptonuria (AKU). AKU is a genetic deficiency of homogentisic acid dioxygenase, causing high levels of homogentisic acid (HGA...
Programme: FP7-HEALTH
Record Number: 106157
Last updated on: 2017-07-12
VitaminD3-Omega3-Home Exercise- HeALTHy Ageing and Longevity Trial
ID: 278588
Start date: 2012-01-01, End date: 2018-06-30
As the European population is ageing rapidly, the growing number of seniors with age-related chronic diseases poses a challenge on European societies and health care systems. Therapeutic interventions that are effective, affordable and well-tolerated in the prevention of chro...
Programme: FP7-HEALTH
Record Number: 103473
Last updated on: 2017-07-12
The European Network for Translational Research in Atrial Fibrillation
ID: 261057
Start date: 2010-11-01, End date: 2015-10-31
The initiation and perpetuation of atrial fibrillation (AF) can be regarded as a complication of a progressive transformation of the structure and functional properties of the atria. This transformation is the result of complex and multiple changes at the molecular, cellular ...
Programme: FP7-HEALTH
Record Number: 96749
Last updated on: 2017-07-12
Integrated research on DEvelopmental determinants of Aging and Longevity
ID: 259679
Start date: 2011-02-01, End date: 2016-01-31
IDEAL will obtain insight into the role of early life conditions affecting late-life health, disease and aging, and the role of epigenetic regulation therein. IDEAL will identify the determinants and targets of this epigenetic regulation utilizing a resource of unique human c...
Programme: FP7-HEALTH
Record Number: 98424
Last updated on: 2017-07-12
Metastatic tumours facilitated by hypoxic tumour micro-environments
ID: 222741
Start date: 2009-02-01, End date: 2014-07-31
Recent research suggests that the hypoxic micro-environment of tumours is one of the major drivers of metastatic spread of cancer. Furthermore, hypoxic tumour micro-environments may result in treatment resistance of cancer cells, therefore causing a double effect of reducing ...
Programme: FP7-HEALTH
Record Number: 91061
Last updated on: 2017-07-12
Personalized diagnosis and treatment of hyperinsulinemic hypoglycaemia caused by beta-cell pathology
ID: 602812
Start date: 2014-04-01, End date: 2018-03-31
Background: Hyperinsulinaemic hypoglycaemia (HH) is a potentially lethal disease caused by over functioning beta cells derived from the pancreatic islets of Langerhans. Lethal HH and brain damage is a problem especially in infants with congenital HH. Current therapeutic appro...
Programme: FP7-HEALTH
Record Number: 185455
Last updated on: 2017-07-02
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List retrieved on: 2017-07-26
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