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Horizon 2020 project information and now also report summaries are available on CORDIS. All H2020 projects can be downloaded from the EU Open Data Portal .

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Results 1 - 10 of 56
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HEPATIC MICROFLUIDIC BIOREACTOR
[PROJECT] HEMIBIO - HEPATIC MICROFLUIDIC BIOREACTOR
ID: 266777
Start date: 2011-01-01, End date: 2015-12-31
The goal of HeMiBio is to develop a hepatic microfluidic bioreactor from human iPSC-derived hepatocytes, hepatic sinusoidal endothelial cells (HSEC) and stellate cells (HSC), suitable for inclusion in a repeated dose toxicity testing strategy of pharmaceuticals/cosmetic ingre...
Programme: FP7-HEALTH
Record Number: 105662
Last updated on: 2017-06-12
Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance
ID: 223545
Start date: 2008-11-01, End date: 2012-10-31
Mismatch2model: Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance DNA mismatch repair (MMR) plays a crucial role in the maintenance of genomic stability. In both bacteria and eukaryotes,...
Programme: FP7-HEALTH
Record Number: 88358
Last updated on: 2017-05-30
Mathematical modelling of beta-catenin and ras signalling in liver and its impact on proliferation, tissue organization and formation of hepatocellular carcinomas
ID: 223188
Start date: 2008-11-01, End date: 2011-10-31
The goal of the CANCERSYS project is to establish a multi-scale model for two major signalling pathways involved in the formation of hepatocellular carcinoma, the beta-catenin and ras signalling pathways. Integrative studies linking measurements in primary heptocytes with eff...
Programme: FP7-HEALTH
Record Number: 88500
Last updated on: 2017-05-30
Genomic determinants of inflammation: from physical measurements to system perturbation and mathematical modeling
ID: 222008
Start date: 2008-12-01, End date: 2012-05-31
Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to sev...
Programme: FP7-HEALTH
Record Number: 88915
Last updated on: 2017-05-30
Search for new therapeutic agents against complicated obesity by reprofiling existing drugs
ID: 223713
Start date: 2008-12-01, End date: 2012-05-31
Obesity is one of the most serious and fast-growing health problem in the European Union, and a leading cause of diabetes. The main barrier for approval of an anti-obesity drug is the safety requirements. We propose to overcome this barrier by discovering phenotypes and bioma...
Programme: FP7-HEALTH
Record Number: 88879
Last updated on: 2017-05-29
A systems approach linking genotype and environment to phenotype: oxidative stress response mechanisms in fission yeast
ID: 223539
Start date: 2008-10-01, End date: 2012-03-31
Cellular protection against oxidative damage is relevant to ageing and numerous complex diseases. We plan to use fission yeast as a model organism to gain a systems-level understanding of the oxidative stress response and obtain insights into the interplay of variable genotyp...
Programme: FP7-HEALTH
Record Number: 88522
Last updated on: 2017-05-29
Ascertaining Barriers for Compliance: policies for safe, effective and cost-effective use of medicines in Europe
ID: 223477
Start date: 2009-01-01, End date: 2012-06-30
Medication non-compliance is highly prevalent across all medical conditions, and represents a major barrier for realising the benefits of evidence-based therapies. The aim of the project is to produce evidence-based policy recommendations for improving patient compliance and ...
Programme: FP7-HEALTH
Record Number: 88878
Last updated on: 2017-05-29
Systems biology of phagosome formation and maturation, modulation by intracellular pathogens
ID: 223451
Start date: 2008-11-01, End date: 2012-04-30
To address the question of how intracellular pathogens modulate phagosome trafficking in the host cell we propose to use a systems biology approach, using an iterative cycle of experimental data, model, new experimental data, improved model. The ultimate aim of our project is...
Programme: FP7-HEALTH
Record Number: 88488
Last updated on: 2017-05-29
Cis-regulatory logic of the transcriptional control in neural stem cells
ID: 223210
Start date: 2008-10-01, End date: 2012-03-31
Neural stem cells (NSCs) have emerged as a major topic in neurobiology. The persistence of multipotent cells in the adult mammalian brain offers a realistic chance for the treatment of neurodegenerative diseases. It is thus crucial to understand NSCs from as many as possible ...
Programme: FP7-HEALTH
Record Number: 88208
Last updated on: 2017-05-29
Tackling the future challenges in Systems Biology
ID: 223137
Start date: 2008-08-01, End date: 2012-01-31
The emerging field of Systems Biology is anticipated to have a major impact on the biosciences, moving biology from a phenomenological to a predictive science. Such predictive ability should allow to accurately foresee the outcome of therapeutic interventions with individual ...
Programme: FP7-HEALTH
Record Number: 88851
Last updated on: 2017-05-29
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List retrieved on: 2017-07-27
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