Community Research and Development Information Service - CORDIS

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Exploiting plants for the production of future generation recombinant pharmaceuticals
ID: 269110
Start date: 2011-08-01, End date: 2019-01-31
Biopharmaceutical proteins are typically produced in cultivated mammalian cells, a costly process with limited scalability. Thus products such as monoclonal antibodies are very expensive and often beyond the reach of the world’s poor. The problem is compounded by the fact tha...
Programme: FP7-IDEAS-ERC
Record Number: 99830
Last updated on: 2017-11-20
Lymphocyte microRNAs in health and disease: Understanding lymphocyte functions through the identification of microRNA target genes and exploiting serum microRNA signatures to monitor immune responses
ID: 269022
Start date: 2011-06-01, End date: 2016-05-31
Background: CD4+ T lymphocyte subsets orchestrate immune responses in health and disease. Little is known on control of T cell differentiation exerted by microRNA that affect mRNA translation. The identification of microRNA and their targets that regulate differentiation of T...
Programme: FP7-IDEAS-ERC
Record Number: 99074
Last updated on: 2017-11-20
Eukaryotic genomic origins, parasites, and the essential nature of mitochondria
ID: 268701
Start date: 2011-03-01, End date: 2017-02-28
Understanding the origin and evolution of eukaryotes, their genomes and organelles, are among the most important and exciting challenges facing biology. However, determining ancient gene origins tests methods and data to their limits, and it is unrealistic to expect progress ...
Programme: FP7-IDEAS-ERC
Record Number: 98151
Last updated on: 2017-11-20
Disseminating tumor cells as novel biomarkers: Dissecting the metastatic cascade in cancer patients
ID: 269081
Start date: 2011-08-01, End date: 2016-07-31
Breast, prostate, lung and colorectal cancer as solid tumours derived from epithelial tissues are responsible for 90% of all new cancers in Europe. Present tumour staging is mainly based on local tumour extension, metastatic lymph node involvement and evidence of overt distan...
Programme: FP7-IDEAS-ERC
Record Number: 99776
Last updated on: 2017-11-20
Mapping the life histories of T cells
[PROJECT] LIFE-HIS-T - Mapping the life histories of T cells
ID: 268733
Start date: 2011-05-01, End date: 2017-01-31
T cells display many different phenotypes and functions, depending on the nature of previously encountered signals. If we want to understand how these different T cell subsets arise, we need to be able to follow individual T cells and their progeny through time. With the aim ...
Programme: FP7-IDEAS-ERC
Record Number: 98547
Last updated on: 2017-10-06
The Immune function of NK cells
ID: 268537
Start date: 2011-07-01, End date: 2016-12-31
In this project, we propose to explore a new area in biological research aiming at dissecting emerging of properties of the innate immune responses. Our system model is the Natural Killer (NK) cell. Specifically, we will investigate the mechanisms by which these players of in...
Programme: FP7-IDEAS-ERC
Record Number: 99481
Last updated on: 2017-10-06
Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
ID: 268548
Start date: 2011-06-01, End date: 2017-02-28
In the present proposal, we plan to examine the dendrites, axons, and presynaptic terminals of fast-spiking, parvalbumin-expressing GABAergic interneurons using subcellular patch-clamp methods pioneered by the PI, imaging techniques, and computational approaches. The goal is ...
Programme: FP7-IDEAS-ERC
Record Number: 98450
Last updated on: 2017-09-24
Programmed and unprogrammed genomic rearrangements during the evolution of yeast species
ID: 268893
Start date: 2011-06-01, End date: 2016-05-31
By detailed evolutionary comparisons among multiple sequenced yeast genomes, we have identified several unusual regions where our preliminary evidence suggests that previously unknown molecular biology phenomena, involving rearrangement of genomic DNA, are occurring. I now pr...
Programme: FP7-IDEAS-ERC
Record Number: 99149
Last updated on: 2017-09-03
Resistance systems and population structure of parasites
ID: 268853
Start date: 2011-05-01, End date: 2016-04-30
The study of parasitism is important for human welfare but also addresses basic scientific questions cutting across biological disciplines. Traditionally, studies of host-parasite interactions have used various scenarios of how genotypes of the two parties interact based on w...
Programme: FP7-IDEAS-ERC
Record Number: 98818
Last updated on: 2017-09-03
The neurobiology of schemas: knowledge acquisition and consolidation
ID: 268800
Start date: 2011-06-01, End date: 2016-05-31
This Co-Investigator Application is an interdisciplinary experimental analysis of the neurobiological mechanisms by which we acquire knowledge. Our approach builds on the foundations of contemporary cognitive neuroscience, particularly ideas about the neural mechanisms of dec...
Programme: FP7-IDEAS-ERC
Record Number: 99030
Last updated on: 2017-09-03
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List retrieved on: 2017-11-25
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