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Nutrient sensing by parasites
[PROGETTO] PARASITENUTRISENSING - Nutrient sensing by parasites
ID: 311502
Data di inizio: 2012-12-01, Termine: 2017-11-30
As any other obligate parasite, Plasmodium depends on its hosts and on the nutrients they provide to survive and complete its life cycle. Surprisingly, nothing is know about Plasmodium’s capacity to sense nutrients or its host’s nutritional status and thereby reprogram its me...
Programme: FP7-IDEAS-ERC
Record Number: 106248
Last updated on: 2017-11-20
The Past, Present and Future of Neotropical Biodiversity
ID: 311024
Data di inizio: 2013-01-01, Termine: 2017-12-31
The American tropics – the Neotropics – comprise more species than any other region on Earth, including thousands of species used as crops, medicines and crafts. Understanding the evolution of this biodiversity and predicting the effects of climate and habitat changes on spec...
Programme: FP7-IDEAS-ERC
Record Number: 106506
Last updated on: 2017-11-20
Mapping canine genes and pathways to leverage personalized treatment options
ID: 310203
Data di inizio: 2012-12-01, Termine: 2017-11-30
The domestic dog encompasses hundreds of genetically isolated breeds, many of which show an increased risk for certain diseases. With the canine genome sequence, an understanding of the haplotype structure and availability of disease gene mapping tools, we are now in a unique...
Programme: FP7-IDEAS-ERC
Record Number: 106246
Last updated on: 2017-11-20
Investigating Hereditary Cancer Predisposition – a combined genomics approach
ID: 310018
Data di inizio: 2013-05-01, Termine: 2019-04-30
Background: Hereditary cancer is an important cause of morbidity and mortality and over the last 20 years, the majority of highly penetrant risk alleles such as BRCA1, BRCA2 in breast cancer and APC, MLH1, MSH2 in colon cancer have been identified. However, there are many men...
Programme: FP7-IDEAS-ERC
Record Number: 108266
Last updated on: 2017-11-20
Keeping gene expression in check: eliciting the role of transcription in the maintenance of genome integrity
ID: 309612
Data di inizio: 2012-11-01, Termine: 2018-10-31
Genomic integrity is essential for accurate gene expression and epigenetic inheritance. On the other hand, a prolonged transcriptional arrest can challenge genome stability, contributing to genetic and epigenetic defects and the mechanisms of ageing and disease. Here we aim t...
Programme: FP7-IDEAS-ERC
Record Number: 105066
Last updated on: 2017-11-20
Following the Genomic Footprints of Early Europeans
ID: 311413
Data di inizio: 2012-10-01, Termine: 2017-09-30
Two of greatest challenges of the post-genomic era are to (i) develop a detailed understanding of the heritable variation in the human genome, and to (ii) determine which key events in human evolutionary history that are responsible for patterns of genomic variation. The rece...
Programme: FP7-IDEAS-ERC
Record Number: 105331
Last updated on: 2017-10-06
Solving an evolutionary jigsaw puzzle: A next-generation genomics approach to trace the origins of the eukaryotic cell
ID: 310039
Data di inizio: 2012-11-01, Termine: 2017-10-31
The origin of the eukaryotic cell represents an enigmatic yet dramatically incomplete evolutionary puzzle. The few pieces of this puzzle that we have managed to identify thus far indicate that the eukaryotic cell most probably emerged via a fusion of an archaeal and an alphap...
Programme: FP7-IDEAS-ERC
Record Number: 105594
Last updated on: 2017-10-06
Microbial opsins for mammalian vision: Optogenetics in the retina
ID: 309776
Data di inizio: 2012-12-01, Termine: 2018-11-30
The retina – a thin sheet of neural tissue in the back of the eye – is a sophisticated image processor which analyzes the incoming light pattern through a set of separate spatio-temporal channels and relays this information to the brain. The loss of the visual sense due to re...
Programme: FP7-IDEAS-ERC
Record Number: 106060
Last updated on: 2017-10-06
Protection against reactive oxygen species in neurodegeneration
ID: 311394
Data di inizio: 2013-02-01, Termine: 2018-05-31
Oxidative stress (OS) is implicated in the pathogenesis of some of the most devastating neurological diseases. Therefore, identification of pathways that counteract oxidative damage may lead to therapeutic strategies applicable to a wide range of disorders. I have recently id...
Programme: FP7-IDEAS-ERC
Record Number: 106704
Last updated on: 2017-09-24
Proliferation and Migration under External Constraints
ID: 311205
Data di inizio: 2013-01-01, Termine: 2018-06-30
Cell proliferation lies at the heart of the threat posed by tumours. It involves cellular growth, division and migration. The tissue surrounding a tumor physically limits its proliferation, which implies that cells that are able to produce effective tumour growth, as well as ...
Programme: FP7-IDEAS-ERC
Record Number: 106353
Last updated on: 2017-09-24
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List retrieved on: 2017-11-20