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Regulation of Chromatin by Combinatorial DNA and Histone Modifications
ID: 309952
Data di inizio: 2013-05-01, Termine: 2019-04-30
The normal expression of genes is tightly regulated. Modifications on histones or on DNA play a central role in the control of gene expression and errors in their regulation often result in diseases such as cancer. These modifications can recruit proteins that regulate chroma...
Programme: FP7-IDEAS-ERC
Record Number: 107360
Last updated on: 2017-11-20
Dynamic sensory-motor integration  in spinal circuits
ID: 311673
Data di inizio: 2013-02-01, Termine: 2018-01-31
Although locomotion may seem effortless, it relies on spinal circuits producing extraordinarily complex patterns of muscle contractions. Graded movements occur over a wide range of amplitudes and frequencies, instantaneously adapting to changes in the environmental or inner s...
Programme: FP7-IDEAS-ERC
Record Number: 106880
Last updated on: 2017-11-20
Definition and characterization of type I interferonopathies
ID: 309449
Data di inizio: 2013-03-01, Termine: 2018-10-31
Although the concept of grouping Mendelian disorders associated with an up-regulation of type I interferon (IFN) has not been previously recognised in the medical literature, my past and current work argues that this concept has scientific validity and clinical utility. I bel...
Programme: FP7-IDEAS-ERC
Record Number: 107398
Last updated on: 2017-11-20
Molecular determinants of aphid host range
ID: 310190
Data di inizio: 2013-02-01, Termine: 2018-10-31
Many aphid species are restricted to one or few host plants, while some aphids, many of which are of agricultural importance, can infest a wide range of plant species. An important observation is that aphids spend a considerable time on nonhost species, where they probe the l...
Programme: FP7-IDEAS-ERC
Record Number: 105786
Last updated on: 2017-11-20
Nutrient sensing by parasites
[PROGETTO] PARASITENUTRISENSING - Nutrient sensing by parasites
ID: 311502
Data di inizio: 2012-12-01, Termine: 2017-11-30
As any other obligate parasite, Plasmodium depends on its hosts and on the nutrients they provide to survive and complete its life cycle. Surprisingly, nothing is know about Plasmodium’s capacity to sense nutrients or its host’s nutritional status and thereby reprogram its me...
Programme: FP7-IDEAS-ERC
Record Number: 106248
Last updated on: 2017-11-20
Impact of virus infection on the host proteome
ID: 311339
Data di inizio: 2012-11-01, Termine: 2017-10-31
Pathogens exploit cellular resources for their own benefit and their propagation. Co-evolution of viruses and their hosts led to the establishment of very specific interactions between both partners. The balance between both, the viral attack and the cellular defense mechanis...
Programme: FP7-IDEAS-ERC
Record Number: 105790
Last updated on: 2017-11-20
The Past, Present and Future of Neotropical Biodiversity
ID: 311024
Data di inizio: 2013-01-01, Termine: 2017-12-31
The American tropics – the Neotropics – comprise more species than any other region on Earth, including thousands of species used as crops, medicines and crafts. Understanding the evolution of this biodiversity and predicting the effects of climate and habitat changes on spec...
Programme: FP7-IDEAS-ERC
Record Number: 106506
Last updated on: 2017-11-20
Mapping canine genes and pathways to leverage personalized treatment options
ID: 310203
Data di inizio: 2012-12-01, Termine: 2017-11-30
The domestic dog encompasses hundreds of genetically isolated breeds, many of which show an increased risk for certain diseases. With the canine genome sequence, an understanding of the haplotype structure and availability of disease gene mapping tools, we are now in a unique...
Programme: FP7-IDEAS-ERC
Record Number: 106246
Last updated on: 2017-11-20
Investigating Hereditary Cancer Predisposition – a combined genomics approach
ID: 310018
Data di inizio: 2013-05-01, Termine: 2019-04-30
Background: Hereditary cancer is an important cause of morbidity and mortality and over the last 20 years, the majority of highly penetrant risk alleles such as BRCA1, BRCA2 in breast cancer and APC, MLH1, MSH2 in colon cancer have been identified. However, there are many men...
Programme: FP7-IDEAS-ERC
Record Number: 108266
Last updated on: 2017-11-20
Keeping gene expression in check: eliciting the role of transcription in the maintenance of genome integrity
ID: 309612
Data di inizio: 2012-11-01, Termine: 2018-10-31
Genomic integrity is essential for accurate gene expression and epigenetic inheritance. On the other hand, a prolonged transcriptional arrest can challenge genome stability, contributing to genetic and epigenetic defects and the mechanisms of ageing and disease. Here we aim t...
Programme: FP7-IDEAS-ERC
Record Number: 105066
Last updated on: 2017-11-20
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List retrieved on: 2017-11-25