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Hematological and Metabolic Aspects of Laboratory Medicine-3rd Ed

Contributed by: Aurelian Udristioiu

From 2016-11-21 to 2017-12-31, Romania
Book: “Hematological and Metabolic Aspects of Laboratory Medicine-3rd Edition”. ISBN: 978-3-330-00548-8. Editor, Alina Covali, Author Aurelian Udristioiu, Published, 21-11-2016, LAP LAMBERT Academic Publishing GmbH & Co. KG Heinrich-Böcking-Str. 6-8 , 66121, Saarbrücken, Germany, November 2016., discovery of carcinogenesis mechanisms, especially from onco-hematology field, Leukemia.
Aurelian Udristioiu, M.D,
Man of medical year/2015, Award, International Bibliographic Center, Cambridge, UK.
The medical book, "Hematological and Metabolical Aspects of Laboratory Medicine", 3-nd edition, continues the analysis of hematologic and metabolic aspects of the 3-nd edition, in the context of international fundamental research. The volume is again successful Romanian medical school in abroad, and through this book brings a substantial contribution of Romanian medicine to universal medicine. It is not possible in this review, limited inevitably to be analyzed numerous data presented in the 15 chapters, but we emphasize the following:

- "Energy levels of the metabolic pathways in malignant B and T lymphocytes in Review", the chapter presents the latest evidence from the literature on cellular metabolites that may be oncogenic by modifying cell signaling and blocking cellular differentiation. Advances in cancer metabolism research in the last decade have increased our understanding on aerobic glycolysis, anaerobic and other metabolic changes that are associated with cell growth and proliferation.

Blocking apoptosis in malignant diseases may be due to the high concentration of ATP from anaerobic metabolism. Energy difference between anaerobic ATP B and T lymphocytes in peripheral blood samples from hematopoietic malignancies measured by bioluminescence was 2.68 μM ATP, a value that appears as an energy transfer between normal B cells and T cells. The energy level can initiate the process of carcinogenesis by suppressing the activity of anti-oncogene proteins. It is concluded that anabolic metabolism in B and T cells in hematological malignancies are under complex regulatory control, directed by receptors on the cell membrane associated with an increase in signal transduction in cells transformed into malignancy.

The research paper " Endogenous effects of alcohol on liver function " sends a signal to the population as grim statistics that mortality from alcoholic liver disease in recent years has been higher than the of several major forms of cancer such as breast, colon and prostate .

An international AASLD / ACG 2010 national guidance on the treatment of severe alcoholic hepatitis is proposed to be necessary in all treatment centers for liver disease due to chronic alcoholism.

- In the chapter " Drugs -induced hemolytic anemia " is presented a case that the best illustrates the cases of laboratory with drug-induced hemolytic anemia ( DIHA ) which are rarely discovered, and for this a specialized laboratory is often required to be performed with optimal serological tests to confirm the diagnosis. Some of the mechanisms involved in DIHA are controversially.

Unfortunately, most drugs that cause severe intravascular hemolysis, anemia, renal failure, disseminated intravascular coagulation times and even death, may have different mechanisms and typically involves drug addiction drug antibodies that trigger activity in serum total complement became the context of autoimmune hemolytic anemia.

The following chapters convince the readers that this issues is addressed to medical personal for all specialties which can find the ideas on physiology, pathophysiology in the light of current concepts and modern principles.
Interests of doctors in all specialties , medical students , staff working in clinical laboratories from 21 countries on five continents where the book is posted on sites, is based on the fact that this paper constitutes a large volume of data, experiences, clinical and laboratory research in a systematic and logical display. The new volume of para-clinical specialty rests on a solid scientific information , rigorously confronted with the author's own experience gained in basic medical education in the country and abroad.

Biochim, PhD, Sorin Gijiu, Emegency Hospital Clinical University, City Timisoara, Romania
Member of American Academy of Clinical Biochemistry, (AACC/NACB) Washington D.C, USA



    Aurelian Udristioiu
    Emergency County Hospital City Targu Jiu
    210218 Targu Jiu


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