Community Research and Development Information Service - CORDIS

JRC to call for biochemical studies

Prior information has been released on a contract to provide studies on 13 areas of interest to the European Commission's Joint Research Centre (JRC).

The studies will be on the following subjects:

- evaluation of biocompatibility of metal-based biomedical implants by in vitro toxicity testing;

- in vitro models of metal-induced infertility and spermiotoxicity;

- in vitro cellular biotransformation of metal compounds;

- data collection in the fields of in vitro neurotoxicity and biocompatibility testing of medical devices;

- chronic in vitro toxicity testing: novel cell culture assay systems;

- prevalidation and validation of metabolically-competent in vitro systems for predicting metabolism-mediated toxicity;

- refinement of Olive (GLP online in vitro toxicology ECVAM) database systems;

- induction of conformational changes in p53 mutants and modulation of sensitivity to selective anti-cancer drugs;

- in vitro assessment of the effects of fluoride compounds on human tissues;

- biostatistical methods applied to in vitro toxicological prevalidation and validation studies;

- development and refinement of Caco-2 cells as an in vitro model of intestinal barrier function;

- prevalidation of in vitro tests for cardiotoxicity;

- safety testing of cosmetic products on human volunteers.

These calls should be officially opened in the second and third quarters of this year.
Follow us on: RSS Facebook Twitter YouTube Managed by the EU Publications Office Top