Descrizione del progetto
Le lectine e i polifenoli delle alghe potrebbero aiutarci a combattere i virus
Le microalghe sono piccole fabbriche le cui complesse vie metaboliche sfornano molti composti bioattivi di interesse per l’industria medica e farmaceutica. Tra questi vi sono le lectine e i polifenoli, noti per varie attività salutari e protettive, annoverando proprietà antibatteriche, antimicotiche, antiossidanti e antinfiammatorie. Più recentemente, si è scoperto che molte lectine e polifenoli possiedono un’attività antivirale. Con il sostegno del programma di azioni Marie Sklodowska-Curie, il progetto AlgaeNet4AV creerà una rete di formazione per esplorare e sfruttare lectine e polifenoli microalgali con proprietà antivirali contro ceppi pandemici di influenza e coronavirus. Il progetto comprenderà la scoperta basata sull’omica, la caratterizzazione, lo sviluppo di sistemi di coltura, la valutazione del mercato, la progettazione di bioraffinerie e la valutazione tecno-economica e di sostenibilità.
Obiettivo
The AlgaeNet4AV project seeks to exploit the microalgae biodiversity, as a source for high-added-value lectins and polyphenols with antiviral properties against influenza and coronavirus pandemic strains. Microalgae derived-compounds are easily amendable, bio-degradable, non-toxic and safe; thus, they are preferred to be used for the development of novel bio-based materials and cosmetics with antiviral potential. Lectins and polyphenols could be highly demanded non-drug interventions across the materials and cosmetics industry as a solution to reduce the risk and speed of contamination and transmission during pandemic outbreaks. The project will combine the whole value chain in order to: a) develop transcriptomics and metabolomics resources from microalgae diversity as a valuable source for the discovery novel lectins and polyphenols; b) characterize their spectrum of bioactivity and toxicity and provide structure-function relationships; c) develop and optimize application-based microalgae culture systems and downstream processing strategies for higher production rate of the desired compounds; d) develop, formulate and evaluate lectins and polyphenols-based final cosmetics products. The work will be supported by market assessment, integral biorefinery designs, techno-economic and sustainability assessment. Integrated value chains will be demonstrated to deliver proof-of-concept and demonstrate economic feasibility. AlgaeNet4AV is an industry-academia R&D and innovation project with a multidisciplinary approach aimed at generating robust business cases through technology development. The consortium composed by 11 partners, with 7 European and 2 third-country (USA & Japan) prominent research organisations. Strong industrial leadership is guaranteed through the participation of 5 SMEs. The projects goals will be achieved through a sustainable way helping meet the increasing demand while creating a positive environmental impact through reduction of carbon emissions.
Campo scientifico
Parole chiave
Programma(i)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Meccanismo di finanziamento
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinatore
57001 Thermi Thessaloniki
Grecia