Objective Despite dramatic advances in molecular and imaging technologies and nearly 1 5,000 articles on schizophrenia and depression (S&D) there are few novel treatments. We think this is because of three major “bottle-necks”: a lack of etiologically-driven or pathophysiologically-accurate animal models; a lack of tests that provide indication of efficacy in healthy volunteers; and the reliance of clinical trials on DSM categories which provide a collection of biologically heterogeneous patients. Our broad working hypothesis is that a focus on cross-species endophenotypes, testing in healthy volunteers and finding biologically-homogenous groups of patients will overcome existing limitations in target identification, early triage and clinical trials. To implement this idea six leading European institutions and two SMEs will partner with the EFPIA to: a) develop animal models that carry confirmed genetic risks, and in these animals to focus on cross-species endophenotypes (e.g. cognitive function, electrophysiology) to facilitate new drug discovery; b) validate the use of fMRI-based endopheno types in genetically-selected healthy volunteers and patients as early and surrogate markers for efficacy; and to combine this with PET approaches for plasma-kinetics to brain-dynamics modelling to provide guidance regarding optimal clinical trial design; and c) identify pharmacogenetic and multi-omic biomarkers that can be used to stratify patients within an umbrella DSM-diagnosis, thus allowing for ) targeted clinical trials, individualized treatment and back-translation of subgroup-specific biomarkers into preclinical drug discovery. To increase the chance of a breakthrough we will implement new analytical approaches (e.g. support vector machine learning algorithms; Bayesian analyses) and willactively collaborate with other ongoing international efforts (esp. the Biomarkers Consortium, NIH). Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesneurobiologycognitive neurosciencemedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesclinical medicinepsychiatryschizophrenianatural sciencescomputer and information sciencesartificial intelligencemachine learning Programme(s) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Topic(s) IMI-JU-01-2008-10 - New Tools For The Development Of Novel Therapies In Psychiatric Disorders Call for proposal IMI-JU-01-2008 See other projects for this call Funding Scheme JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinator H. LUNDBECK AS EU contribution No data Address OTTILIAVEJ 7-9 2500 Valby Denmark See on map Region Danmark Hovedstaden Byen København Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Principal investigator Tine Bryan Stensbøl (Dr) Administrative Contact Ejner Moltzen (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (19) Sort alphabetically Sort by EU Contribution Expand all Collapse all KING'S COLLEGE LONDON United Kingdom EU contribution € 2 592 966,00 Address STRAND WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 792 550,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Karin Blomberg (-) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 1 333 476,00 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Renata Schaeffer (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT Germany EU contribution € 1 149 873,00 Address Square J 5 68159 Mannheim See on map Region Baden-Württemberg Karlsruhe Mannheim, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Petra Seebauer-Enste (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 682 467,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Alberto Sereno Alvarez (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 604 471,00 Address OXFORD ROAD M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Liz Fay (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Psynova Neurotech Ltd United Kingdom EU contribution € 40 226,00 Address St, Johns Innovation Centre, Cowley Road CB4 0WS Cambridge See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Barbara Baron (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISLENSK ERFDAGREINING EHF Participation ended Iceland EU contribution € 869 378,00 Address STURLUGOTU 8 101 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Frosti Jonsson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Germany EU contribution € 564 810,00 Address OSKAR VON MILLER RING 29 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Fuchs (Mrs) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASTRAZENECA AB Participation ended Sweden EU contribution No data Address Vastra Maelarhamnen 151 85 Sodertaelje See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eva Lindgren (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ELI LILLY AND COMPANY LTD United Kingdom EU contribution No data Address LILLY HOUSE BASINGVIEW RG21 4FA Basingstoke See on map Region South East (England) Hampshire and Isle of Wight North Hampshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Steckel-Hamann (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JANSSEN PHARMACEUTICA NV Belgium EU contribution No data Address TURNHOUTSEWEG 30 2340 Beerse See 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Antwerpen Arr. Turnhout Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Henk Sipma (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NOVARTIS PHARMA AG Switzerland EU contribution No data Address LICHTSTRASSE 35 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Barbara Stolz (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ORION OYJ Finland EU contribution No data Address ORIONINTIE 1 02200 Espoo See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Reijo Salonen (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PFIZER LIMITED United Kingdom EU contribution No data Address RAMSGATE ROAD CT13 9NJ Sandwich See on map Region South East (England) Kent East Kent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Olga Krylova (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data F. HOFFMANN-LA ROCHE AG Switzerland EU contribution No data Address GRENZACHERSTRASSE 124 4070 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Luca Santarelli (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT DE RECHERCHES SERVIER France EU contribution No data Address 3 Rue de la Republique 92150 Suresnes See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Esther SCHENKER (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BAR ILAN UNIVERSITY Israel EU contribution € 355 999,00 Address BAR ILAN UNIVERSITY CAMPUS 52900 Ramat Gan See on map Activity type Higher or Secondary Education Establishments Administrative Contact Moshe Salomon (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ABBVIE DEUTSCHLAND GMBH & CO KG Germany EU contribution No data Address MAINZER STR. 81 65205 Wiesbaden See on map Region Hessen Darmstadt Wiesbaden, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Matthew Emsley (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data