Objective Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future attempts to build a quantitative, ‘systems-based’ description of cell biology. However, current ‘first generation’ proteomics approaches largely measure protein complexes and proteomes as homogeneous and static entities with little or no quantitative annotation. PROSPECTS (PROteomics SPECification in Time and Space) is a proposal by world leaders in this young discipline to make a major advance, both by developing much more powerful instrumentation and by applying novel proteomics methods that will allow us to annotate quantitatively the human proteome with respect to protein localization and dynamics. Complementary technologies, including mass spectrometry, cyro-electron microscopy and cell imaging will be applied in innovative ways to capture transient protein complexes and the spatial and temporal dimensions of entire proteomes. We will develop these new proteomics technologies in a generic fashion to maximize their utility to the wider biomedical community and we will generate comprehensive data sets that will foster many downstream functional studies. Our approaches will also generate unique insights into the molecular basis of multiple forms of human disease, specifically neurodegeneration and other diseases related to folding stress. The multidimensional data sets generated in PROSPECTS will be integrated using advanced data aggregation and machine learning, made available to the scientific community via annotated online public databases and used as a basis for a systems biological modelling of the human proteome, with spatial and temporal resolution within the cell. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencescell biologynatural scienceschemical sciencesanalytical chemistrymass spectrometrynatural sciencescomputer and information sciencesartificial intelligencemachine learning Keywords MS based proteomics fluorescence microscopy machine learining modelling neurodegenerative disease protein complexes single particle electron microscopy single particles systems biology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.1-2 - Temporal and spatial proteomics to study biological processes relevant to human health Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV EU contribution € 3 684 968,00 Address HOFGARTENSTRASSE 8 80539 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Anne Katrin Werenskiold (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 1 035 800,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Ruedi Aebersold (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Participation ended United Kingdom EU contribution € 111 408,00 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Dawn Barker (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SYDDANSK UNIVERSITET Denmark EU contribution € 800 500,00 Address CAMPUSVEJ 55 5230 Odense M See on map Region Danmark Syddanmark Fyn Activity type Higher or Secondary Education Establishments Administrative Contact Jens V. Kierkegaard (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THERMO FISHER SCIENTIFIC (BREMEN) GMBH Germany EU contribution € 1 300 000,00 Address HANNA KUNATH STRASSE 11 28199 Bremen See on map Region Bremen Bremen Bremen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ernst Schröder (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PROXEON BIOSYSTEMS A/S Denmark EU contribution € 601 600,00 Address STAERMOSEGARDSVEJ 6 5230 ODENSE See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Hansen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACIO CENTRE DE REGULACIO GENOMICA Spain EU contribution € 799 446,00 Address CARRER DOCTOR AIGUADER 88 08003 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Stefan Pönisch (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF DUNDEE United Kingdom EU contribution € 1 046 019,00 Address Nethergate DD1 4HN Dundee See on map Region Scotland Eastern Scotland Angus and Dundee City Activity type Higher or Secondary Education Establishments Administrative Contact James Houston (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KUNGLIGA TEKNISKA HOEGSKOLAN Sweden EU contribution € 809 162,00 Address BRINELLVAGEN 8 100 44 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact åke Eriksson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE HEBREW UNIVERSITY OF JERUSALEM Israel EU contribution € 1 000 000,00 Address EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem See on map Activity type Higher or Secondary Education Establishments Administrative Contact Eran Vardi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 588 588,00 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Stewart Deakin (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data