Objective "Homogeneous and enzymatic catalyses are in many respects complementary. By anchoring an organometallic catalyst precursor into a host protein, we hoped to create artificial metalloenzymes with properties reminiscent of both areas. To be able to readily deconvolute the influence of the organometallic fragment from the influence of the protein, we want to focus on enantioselective catalysis. Incorporation of an achiral catalyst precursor in the host protein ensures that any level of enantioselection is induce d by the second coordination sphere provided by the protein. Such an approach offers several appealing features: (i) the possibility of dissociating the activity (primarily dictated by the organometallic catalyst precursor) from the selectivity (governed b y the host protein); (ii) the use of orthogonal diversity-generating procedures (molecular biology for the protein optimization as well as parallel synthesis for the organometallic fragment); and (iii) a novel approach to exploit weak interactions in enantioselective homogeneous catalysis. The approach we focus on relies on a non-covalent incorporation (i.e. supramolecular) of the organometallic catalyst precursor in the protein. Since no chemical coupling step is required upon addition of the catalyst precursor to the protein, we reasoned that the integrity of the organometallic species would be warranted. To ensure the localization of the organometallic catalyst precursor within the protein, however, a very strong non-covalent host-guest (i.e. a protein inhibitor) system should be selected." Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencesinorganic chemistryorganometallic chemistrynatural scienceschemical sciencescatalysisbiocatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesnatural sciencesbiological sciencesmolecular biology Keywords Enzymatic catalysis catalysis Supramolecular Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Call for proposal FP6-2004-MOBILITY-6 See other projects for this call Funding Scheme OIF - Marie Curie actions-Outgoing International Fellowships Coordinator UNIVERSITY OF NEUCHATEL EU contribution No data Address Avenue du 1er Mars NEUCHATEL Switzerland See on map Links Website Opens in new window Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all HARVARD UNIVERSITY United States EU contribution No data Address 12 Oxford Street CAMBRIDGE, MA See on map Links Website Opens in new window Total cost No data
