Objective The study of biological processes occurring at the nanoscale is becoming a new discipline at the border between Physics and Biology with major scientific challenges and new technological applications. In fact, interactions at the nanoscale between cells/neurons and surfaces with specific nanopatterns appear to control several major biological processes, such as cell proliferation and differentiation. The aim of the present NanoScale proposal is therefore to explore interactions between stem cells, neurons, neuronal networks and surfaces with specific geometrical nanopatterns and nanoprints of specific proteins and molecules. In order to do so, we have formed an interdisciplinary consortium consisting of five major European research centres (SISSA, TASC-INFM, DTU, NMI and ENS) with two SMEs (MCS, Promoscience) gathering biological knowledge and expertise in the fabrication of nanostructures and of their manipulation. The NanoScale proposal will produce and develop a variety of nanodevices for growing, guiding, manipulating cells, neurons and neuronal cultures. It is composed of two major ingredients: i - the combination of a MicroElectrode Arrays (MEAs) with chemical and topographic micro/nanosubstrates controlling the network growth; ii – the coupling with external measuring and/or manipulating devices such as Electron Microscopes and Optical Tweezers. We expect to provide an answer to new scientific issues and therefore achieving major scientific breakthroughs. In addition, our proposal will produce new knowledge and know-how enabling the development of new marketable products that will be commercialised by MCS. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesphysical sciencesopticsmicroscopymedical and health sciencesmedical biotechnologycells technologiesstem cells Keywords chip microfluidics nanotechnology neurons optical tweezers Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2007-1.1-1 - Nano-scale mechanisms of bio/non-bio interactions Call for proposal FP7-NMP-2007-SMALL-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE EU contribution € 353 952,00 Address VIA BONOMEA 265 34136 Trieste Italy See on map Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Higher or Secondary Education Establishments Administrative Contact Giuliana Zotta (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all CONSIGLIO NAZIONALE DELLE RICERCHE Italy EU contribution € 579 879,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Francesca Fortunati (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DANMARKS TEKNISKE UNIVERSITET Denmark EU contribution € 578 828,00 Address ANKER ENGELUNDS VEJ 101 2800 Kongens Lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Administrative Contact Niels Freese Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ECOLE NORMALE SUPERIEURE France EU contribution € 579 646,00 Address 45, RUE D'ULM 75230 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Administrative Contact Yong Chen (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN Germany EU contribution € 309 700,00 Address MARKWIESENSTRASSE 55 72770 Reutlingen See on map Region Baden-Württemberg Tübingen Reutlingen Activity type Research Organisations Administrative Contact Günter Beck (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MULTI CHANNEL SYSTEMS MCS GMBH Germany EU contribution € 316 520,00 Address ASPENHAUSTRASSE 21 72770 Reutlingen See on map Region Baden-Württemberg Tübingen Reutlingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Karl-Heinz Boven (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PROMOSCIENCE SRL Italy EU contribution € 151 080,00 Address LOCALITA PADRICIANO 99 34012 Trieste See on map Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Manuela Schipizza (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Glance Vision Technologies s.r.l. Italy EU contribution € 160 800,00 Address VIA GIOVANNI SEGANTINI 1/1 34100 Trieste See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Walter Vanzella (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data