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Monolithic Adsorbent Columns for Extracorporeal Medical Devices and Bioseparations

Objective

The aim of the project is to manufacture novel composite 3D monolithic adsorbent columns for use in extracorporeal medical devices for blood purification (haemoperfusion), therapeutic apheresis and cytapheresis and in bioseparations for analytical and commercial applications. It brings together a multidisciplinary consortium of specialists in different areas of synthetic, polymer and surface chemistry, biomedical and biological sciences, engineers and bioengineers, immunologists and medics united by the aim of developing new and efficient means of treatment of patients with currently incurable diseases. It is comprised of 3 SMEs, 3 universities and a medical hospital from 4 EU countries. The main objectives of the project are: to synthesise a range of novel monolithic polymer cryogels ; iito synthesise polymer monoliths (non-functionalised and functionalised with bioligands) with embedded porous cellulose or activated carbon microparticles; to design monolithic adsorption columns for extracorporeal blood purification from molecular solutes and target cells; to evaluate in vitro their biocompatibility and assess mechanical, physical and physicochemical parameters of the monolithic adsorption columns in an extracorporeal circulation; to test columns for their efficiency and selectivity of cytapheresis and adsorption of biological macromolecules in model systems, and with dialysate, ultrafiltrate and whole blood; and to explore a range of future applications for this technology in critical care medicine

Field of science

  • /natural sciences/biological sciences
  • /medical and health sciences/clinical medicine/critical care medicine

Call for proposal

FP7-PEOPLE-2007-3-1-IAPP
See other projects for this call

Funding Scheme

MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP)

Coordinator

UNIVERSITY OF BRIGHTON
Address
Lewes Road Mithras House
BN2 4AT Brighton
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 247 341
Administrative Contact
Gary Phillips (Dr.)

Participants (6)

MAST CARBON INTERNATIONAL LTD
United Kingdom
EU contribution
€ 206 627
Address
Jays Close Viables
RG22 4BA Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stefan Batchelor (Mr.)
Protista Biotechnology AB
Sweden
EU contribution
€ 459 370
Address
Kvarngatan 2
26722 Bjuv
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hans Jungvid (Mr.)
Polymerics GmbH - Spezialpolymere - Klebstoffe - Polymercharakterisierung
Germany
EU contribution
€ 417 770
Address
Landsberger Alle, 378
12681 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
André Leistner (Mr.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 259 559
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Olov Sterner (Dr.)
UNIVERSITAT FUR WEITERBILDUNG KREMS
Austria
EU contribution
€ 292 739
Address
Dr Karl Dorrek Strasse 30
3500 Krems
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Viktoria Weber (Dr.)
BRIGHTON AND SUSSEX UNIVERSITY HOSPITALS NHS TRUST
United Kingdom
EU contribution
€ 177 479
Address
Royal Sussex County Hospital, Eastern Road
BN2 5BE Brighton
Activity type
Research Organisations
Administrative Contact
Scott Harfield (Mr.)