Objective We apply for a Marie Curie Intra-European Fellowship for Dr. Ernest Marco-Urrea from Barcelona, Spain, to the group of Dr. Lorenz Adrian at the Helmholtz-Center in Leipzig, Germany. The fellowship will allow Dr. Marco-Urrea a significant expansion of his research experience which currently is focused in the aerobic degradation of halogenated ethenes by white-rot fungi. Dr. Marco-Urrea has published four referenced papers on this topic and has acquired research experience in the USA, but the next step in his career is clearly the widening of his thematic focus and of his methodological capacities in a European context. Both will be provided by the host. Dr. Marco-Urrea will continue to investigate microbial biodegradation of halogenated compounds. However, he will cultivate and perform biochemical test consistently under anaerobic conditions; he will work with halogenated aromatics rather than with aliphatics; and he will work with bacteria rather than with fungi. He will expand his already wide spectrum of techniques to the quantitative analysis of stable isotopes and to proteomic approaches. The project will complement the work that is planned in the group of Dr. Adrian on Dehalococcoides-like Chloroflexi. Dr. Marco-Urrea's main task will be the investigation of the physiological and biochemical characteristics of strain CBDB1 in an isotopic and proteomic context. Strain CBDB1 is a remarkable organism that can transform highly chlorinated dioxins, biphenyls, phenols and benzenes. It is also unique in terms of physiology, morphology and biochemistry, and its genome is fully sequenced. After an initial training phase in which isotope fractionation during growth with perchloroethene will be investigated, Dr. Marco-Urrea will use biochemical and isotopic methods to identify water-soluble electron acceptors for strain CBDB1. In a third phase, an initial proteome map under standard conditions and with alternative electron acceptors will be determined. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicinephysiologynatural sciencesbiological sciencesgeneticsgenomes Keywords Anaerobic microbiology Applied biology Biodegradation Chlorinated compounds Dehalococcoides Proteomics Reductive dechlorination Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development" Call for proposal FP7-PEOPLE-IEF-2008 See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ EU contribution € 161 563,92 Address PERMOSERSTRASSE 15 04318 Leipzig Germany See on map Region Sachsen Leipzig Leipzig Activity type Research Organisations Administrative Contact Annette Schmidt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
