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Construction kit for tailor-made vascularized boneimplants

Objective

The goal of VascuBone is to develop a “tool box” for bone regeneration, which on one hand fulfils basic requirements and on the other hand is freely combinable with what is needed in the respective patient’s situation. The tool box will include a variation of biocompatible biomaterials and cell types, FDA approved growth factors, material modification technologies, simulation and analytical tools like molecular imaging based in vivo diagnostics which can be combined for the specific medical need. This tool box will be used to develop translational approaches for regenerative therapies of three different types of bone defects. The chosen bone diseases differ in their requirements, to ensure a successful implementation and translation. Additionally this implementation strategy is characterized by high complexity to remove bottlenecks and limitations of bone regeneration identified in the clinical setting. Therefore definite quality criteria have to be evaluated concerning an optimal stem cell source/subpopulation as well as GF concentrations and their bioactivity in vivo. Furthermore quantitative evaluation will focus on the definition of differences between stem cell populations responsible for bone regeneration in young and old people, as a prerequisite for the development of regenerative therapies for the ageing European society. Considering a successful and prompt approval of the biomaterial, for each clinical application a minimum of modification steps in daily routine must be identified. The road map of the project and clinic trials contains pre-determined milestones, to ensure efficacy, safety, and immunological acceptance of the implant. The efficacy is quantified by high innovative MRI and PET/CT technology which is able to demonstrate the regenerative effect of biomaterials and cells in vivo. Based on the clinical data the proposal as “Advanced Therapeutical Medicinal Product” will be submitted to the European Medicines Agency at the end of the project.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug
  • /engineering and technology/industrial biotechnology/biomaterials

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27C
80686 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 2 380 655,59
Administrative Contact
Christoph Schulte (Mr.)

Participants (17)

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 597 280
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Andersz (Ms.)
KOMET RHOBEST GMBH

Participation ended

Austria
EU contribution
€ 367 981
Address
Exlgasse 20A
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Doris Steinmüller-Nethl (Dr.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 357 680
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karin Larsson (Prof.)
JOHNSON & JOHNSON MEDICAL GMBH

Participation ended

Germany
EU contribution
€ 129 883
Address
Robert Koch Strasse 1
22851 Norderstedt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juergen Trzewik (Dr.)
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 1 082 480
Address
Museplassen 1
5020 Bergen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Inger Gjesdahl (Ms.)
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany
EU contribution
€ 1 816 592
Address
Sanderring 2
97070 Wuerzburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Gloggengiesser (Mr.)
OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN
Austria
EU contribution
€ 327 667,86
Address
Dr. Ignaz Seipel-platz 2
1010 Wien
Activity type
Research Organisations
Administrative Contact
Günter Lepperdinger (Dr.)
CellTech Services Götz GmbH

Participation ended

Germany
EU contribution
€ 51 903,41
Address
Uhlandstr. 16
63500 Seligenstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alexander Goetz (Dr.)
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 1 172 180
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Kloss (Prof.)
MRB Forschungszentrum fur Magnet-Resonanz-Bayern e.V.
Germany
EU contribution
€ 898 500
Address
Am Hubland
97074 Wuerzburg
Activity type
Research Organisations
Administrative Contact
Karl-Heinz Hiller (Dr.)
NANOPET PHARMA GMBH
Germany
EU contribution
€ 528 156
Address
Robert-koch-platz 4
10115 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicole Gärtner (Ms.)
PP-POLYMER AB
Sweden
EU contribution
€ 431 899
Address
Krossgatan 15
162 50 Vallingby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ann-Christin Paul (Mrs.)
MEDICYTE GMBH
Germany
EU contribution
€ 742 000
Address
Im Neuenheimer Feld 581
69120 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stefan Holder
TOPASS GMBH
Germany
EU contribution
€ 364 272
Address
Drakestrasse 42
12205 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jutta Vom Brocke (Ms.)
UNIVERSITAET INNSBRUCK
Austria
EU contribution
€ 261 757,14
Address
Innrain 52
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Günter Lepperdinger (Dr.)
DIACOATING GMBH
Austria
EU contribution
€ 374 926
Address
Mitterweg 24
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Armin Partl (Mr.)
EVONIK INDUSTRIES AG
Germany
EU contribution
€ 80 258
Address
Rellinghauser Strasse 1-11
45128 Essen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Rode (Mr.)