Objective This ERC Grant proposal aims to explore the many challenges offered by non-covalent synthesis of functional supramolecular systems. This proposal will use the many possibilities of supramolecular polymers and how we envisage the construction of supramolecular compartmentalized systems based on specific secondary interactions. By studying the mechanisms of the formation of supramolecular polymers, new entrees are foreseen to limit the degree of supramolecular polymers by anti-cooperative mechanisms and to control both the depolymerization and polymerization aiming at supramolecular polymerization processes out of equilibrium. These insights will be used to design, synthesize and self-assembly materials that dynamically adapt their properties to cells that are brought in contact with these biomaterials. With these materials, parts of a bioartificial kidney will be made. With all the knowledge obtained through the years, we have recently introduced a concept to stepwise create folded macromolecules making use of our well-known supramolecular units. These single chain nanoparticles with internal structure are now proposed to be the starting point for making compartmentalized three-dimensional systems that possess functionality similar to proteins. Therefore, also novel techniques to synthesize well-defined polymers are introduced. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural scienceschemical sciencespolymer sciencesengineering and technologynanotechnologynano-materialsengineering and technologyindustrial biotechnologybiomaterials Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-PE5 - ERC Advanced Grant - Materials and Synthesis Call for proposal ERC-2009-AdG See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Host institution TECHNISCHE UNIVERSITEIT EINDHOVEN EU contribution € 1 947 937,00 Address GROENE LOPER 3 5612 AE Eindhoven Netherlands See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Higher or Secondary Education Establishments Administrative Contact S. Sagitta Peters (Ms.) Principal investigator Egbert Willem Meijer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all TECHNISCHE UNIVERSITEIT EINDHOVEN Netherlands EU contribution € 1 947 937,00 Address GROENE LOPER 3 5612 AE Eindhoven See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Higher or Secondary Education Establishments Administrative Contact S. Sagitta Peters (Ms.) Principal investigator Egbert Willem Meijer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
