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Zawartość zarchiwizowana w dniu 2024-05-29

Neural substrates, electrophysiological correlates and dopaminergic modulation of different forms of inhibition in humans

Cel

Malfunctioning of the fronto-striatal circuitry in the brain is thought to lead to a lack of inhibition and thereby to impulsivity, which plays a crucial role in Attention Deficit-Hyperactivity Disorder (ADHD) and drug addiction. Two main categories of inhibition can be distinguished: response (or action) inhibition and inhibition of goal directed behaviour.

Whereas the first category prevents motor impulsivity, the latter category represents cognitive control of the individual to follow his own recognized best interest. It is not known whether both forms of inhibition utilize the fronto-striatal brain circuitry to the same extent or not. Electrophysiological correlates of response inhibition have been shown but electrophysiological evidence of inhibition of goal directed behaviour is lacking.

Further, it is unknown whether the two forms of inhibition are to the same extent dependent on modulation by neurotransmitters such as dopamine. Knowledge about this would greatly facilitate the development of more selective and accurate treatment of ADHD patients. In the proposed research, event-related functional magnetic resonance imaging (fMRI) will be combined with event-related brain potentials (ERP) in healthy human volunteers.

We will investigate whether response inhibition and inhibition of goal directed behaviour differentially utilize the fronto-striatal circuitry or to what extent it differs and disentangle electrophysiological correlates that mediate the two forms of inhibition. Further, the dependence of these neural substrates on dopaminergic modulation will be investigated, by testing the effect of sulpiride on the two forms of inhibition using both fMRI an ERP.

As an eventual goal of the project, event-related fMRI will be used in adult ADHD patients to investigate putative differences between the patients and the healthy volunteers in the functioning and dopaminergic modulation of the neural substrates for the two forms of inhibition.

Dziedzina nauki

Klasyfikacja projektów w serwisie CORDIS opiera się na wielojęzycznej taksonomii EuroSciVoc, obejmującej wszystkie dziedziny nauki, w oparciu o półautomatyczny proces bazujący na technikach przetwarzania języka naturalnego.

Zaproszenie do składania wniosków

FP6-2004-MOBILITY-5
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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Wkład UE
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The Old Schools, Trinity Street
CAMBRIDGE
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