Objective ANTIFLU is to develop innovative drugs against influenza virus infections based on a novelconcept that precludes the development of viral resistance and ensures efficacy againstupcoming pandemic influenza strains. Viral replication is known to depend on multiple hostfactors. Whilst traditional anti-influenza treatments usually target viral factors, ANTIFLU willaim at drugs interfering with host-response pathways. The concept of drugs targeting humanfactors, established in treatment of other diseases, has yet not been sufficiently explored fortreatment of viral infections, although it bears compelling advantages over conventionalantiviral therapies: (i) the avoidance of viral escape mutants and (ii) the broad coverageagainst unprecedented viral variants.ANTIFLU aims to fully exploit this potent approach to fill critical gaps in our current treatmentand prevention options against seasonal and pandemic influenza virus infections. By buildingupon an existing panel of potent human targets and firm knowledge derived from FP6 projectRIGHT, an interdisciplinary consortium will pursue the identification and validation of smallmolecule ligands and inhibitory RNA molecules effective against influenza infection.Promising modulators will form the basis to generate lead molecules that will be furtherrefined to yield clinically applicable therapeutics. Initial preclinical studies will aim at providingproof of concept in animal models, safety and toxicology profiles. They will allow initiatingcomplete clinical trials immediately after the phase of FP7 support, thanks to the commitmentalready taken by investors from the private sector. The consortium includes several SMEs,internationally renowned research groups and clinical institutions with extensive experiencein anti-influenza treatment and clinical trials. An already agreed common exploitation modelwill provide a smooth route to market and optimal use of the project results. Fields of science natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencespublic healthepidemiologypandemicsmedical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health sciencesbasic medicinetoxicologysocial sciencespsychologyergonomics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.3.3-4 - Novel therapeutics against influenza. FP7-INFLUENZA-2010 Call for proposal FP7-INFLUENZA-2010 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV EU contribution € 1 448 954,00 Address HOFGARTENSTRASSE 8 80539 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Birgit Gieding (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all VICHEM CHEMIE KUTATO KORLATOLT FELELOSSEGU TARSASAG Hungary EU contribution € 621 500,20 Address VIOLA UTCA 2 8200 VESZPREM See on map Region Dunántúl Közép-Dunántúl Veszprém Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact György Kéri (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AARHUS UNIVERSITET Denmark EU contribution € 548 576,00 Address NORDRE RINGGADE 1 8000 Aarhus C See on map Region Danmark Midtjylland Østjylland Activity type Higher or Secondary Education Establishments Administrative Contact Karin Sutherland (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LEAD DISCOVERY CENTER GMBH Germany EU contribution € 1 629 860,00 Address OTTO HAHN STRASSE 15 44227 Dortmund See on map Region Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Hamacher (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT PASTEUR France EU contribution € 38 901,00 Address RUE DU DOCTEUR ROUX 25-28 75724 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Nadia Khelef (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARTTIC France EU contribution € 344 000,00 Address 39 RUE DES MATHURINS 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bruno Cucinelli (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDITOX S.R.O Czechia EU contribution € 8 636,00 Address POD ZAMKEM 279 28125 Konarovice See on map Region Česko Střední Čechy Středočeský kraj Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jan Zabsky (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 433 778,00 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Tatjana Palalic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data RiboTask ApS Denmark EU contribution € 222 232,80 Address UNSBJERGVEJ 2 A DK-5220 Odense SO See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jesper Wengel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE HEBREW UNIVERSITY OF JERUSALEM Israel EU contribution € 289 560,00 Address EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem See on map Activity type Higher or Secondary Education Establishments Administrative Contact Hani Ben-Yehuda (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FORSCHUNGSVERBUND BERLIN EV Germany EU contribution € 414 000,00 Address RUDOWER CHAUSSEE 17 12489 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Administrative Contact Anne Höner (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data