Objective Age-related cancers, especially of the trachea, are neoplastic lesions that significantly impact upon the lives of thousands of European patients each year. Unfortunately, most present with inoperable lesions for which median survival is less than 12 months. Based on our previous clinically successful experiences with in vivo completely tissue engineered tracheal replacement in benign tracheal diseases, we recently applied this technology in 2 patients with otherwise inoperable primary tracheal cancers. The successful observed outcome confirms the unique opportunity to scale-up an effective therapeutic approach into a widely accessible clinical technology, which could enhance not only the quality of life but even cure otherwise untreatable patients. However, a limitation of our current technology is the time it takes to re-populate the decellularized trachea. This may prove critical in the case of cancer patients. Further, the size of the transplant is currently limited due to the fact that the transplanted tissue needs to be efficiently and rapidly vascularised to prevent necrosis in vivo. To surmount these limitations, we aim to: i) improve our current technique of in vivo tissue engineering human tracheae in a small number of patients and subsequently begin a formal clinical trial, ii) develop pharmacological approaches to activate endogenous stem cells, stimulate tissue regeneration and vascularisation in situ, iii) develop a synthetic tracheal scaffold using a novel nanocomposite polymer as alternatives to natural human scaffolds and iv) develop good medical practice manufacturing process for safe, efficient and cost effective commercial production. This research project is aimed to define a robust airway implantation technique assuring a better outcome for thousands of patients each year. Moreover, we aim to use these results as a starting point to develop clinical approaches that could improve the treatment of age-related cancers of other hollow organs. Fields of science engineering and technologymechanical engineeringmanufacturing engineeringmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologyengineering and technologyindustrial biotechnologybiomaterials Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2011.2.2-2 - Biomaterials for tissue engineering for age-related cancer and sensory organ diseases Call for proposal FP7-NMP-2011-SMALL-5 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator KAROLINSKA INSTITUTET EU contribution € 1 173 842,00 Address Nobels Vag 5 17177 Stockholm Sweden See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Ylva Hultman (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAET LEIPZIG Germany EU contribution € 181 680,00 Address RITTERSTRASSE 26 04109 Leipzig See on map Region Sachsen Leipzig Leipzig Activity type Higher or Secondary Education Establishments Administrative Contact Doris Stefanowa (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 695 800,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Greta Borg-Carbott (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 366 000,00 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Tatjana Palalic (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA Italy EU contribution € 400 750,00 Address VIA UNIVERSITA 4 41121 Modena See on map Region Nord-Est Emilia-Romagna Modena Activity type Higher or Secondary Education Establishments Administrative Contact Graziella Pellegrini (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI Participation ended Italy EU contribution € 20 900,00 Address LARGO G.A. BRAMBILLA 3 50134 Firenze See on map Region Centro (IT) Toscana Firenze Activity type Research Organisations Administrative Contact Paolo Macchiarini (Prof.) Links Contact the organisation Opens in new window Total cost No data INSTITUT GUSTAVE ROUSSY France EU contribution € 80 400,00 Address Rue Camille Desmoulins 39 94805 Villejuif See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Arnauld Forest (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ROBERT KOCH-INSTITUT Germany EU contribution € 60 000,00 Address Nordufer 20 13353 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Administrative Contact Birgit Arnold (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONSIGLIO NAZIONALE DELLE RICERCHE Italy EU contribution € 205 428,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Loredana De Bartolo (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI Italy EU contribution € 208 800,00 Address VIA GIUSTI 9 50121 Firenze See on map Region Centro (IT) Toscana Firenze Activity type Research Organisations Administrative Contact Daniele Consigli (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INTERCYTEX LTD United Kingdom EU contribution € 192 000,00 Address CREWE ROAD INNOVATION HOUSE M23 9QR MANCHESTER See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Paula Thompson (Ms.) Links Contact the organisation Opens in new window Total cost No data Pharmidex Pharmaceutical Services Limited United Kingdom EU contribution € 124 500,00 Address HANOVER STREET 14 FLOOR 3 W1S 1RR London See on map Region London Inner London — West Westminster Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mo Alavijeh (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HUGO SACHS ELEKTRONIK - HARVARD APPARATUS GMBH Germany EU contribution € 289 200,00 Address GRUNSTRASSE 1 79232 MARCH HUGSTETTEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Roger Zink (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data