Objective The topics of this joint exchange programme are all related to a specific plant genus of commercial interest and its taxonomy, the propagation and investigation of endangered species of this plant genus, the natural products used in medicine occurring in Digitalis plants, and the isolation, structure elucidation and biological testing of some of the rare but pharmacological relevant cardenolides. Objectives are (1) Taxonomically critical Digitalis species and subspecies will be (re)-examined by molecular taxonomy, using the progesterone 5β-reductase gene as a molecular marker, and chemotaxonomy by cardenolide profiling, using HPLC, (2) plant tissue cultures of endangered Digitalis species will be established and used in plant propagation. Hairy root cultures of selected species will be established for fundamental studies on cardenolide formation, (3) the structures of important cardenolides will be elucidated by NMR and bulk quantities of selected cardenolides will be produced, (4) antiviral and antiproliferative effects of individual cardenolides will be studied. Cardenolides will be screened for their pharmacological profiles (potential and selectivity). The objectives aim at intensifying circumstantial ongoing co-operations and exchange of materials and people in a more reliable and coordinated way. The profiles of expertise of the various partners are complementary and researchers from Turkey, Brazil, Germany and Portugal are involved. Fields of science agricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulture Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Call for proposal FP7-PEOPLE-2011-IRSES See other projects for this call Funding Scheme MC-IRSES - International research staff exchange scheme (IRSES) Coordinator FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG EU contribution € 65 100,00 Address SCHLOSSPLATZ 4 91054 Erlangen Germany See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Franziska Müller (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA FP Portugal EU contribution € 58 800,00 Address CAMPO GRANDE EDIFICIO C1 PISO 3 1749 016 Lisboa See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Research Organisations Administrative Contact Ana Cristina Silva Da Figueiredo (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BOLU ABANT IZZET BAYSAL UNIVERSITESI Türkiye EU contribution € 48 300,00 Address GOLKOY KAMPUSU 14280 Merkez See on map Region Ege Manisa Afyonkarahisar Activity type Higher or Secondary Education Establishments Administrative Contact Ekrem Gürel (Prof.) Links Contact the organisation Opens in new window Total cost No data
