Project description Challenging current Thinking Show the project objective Hide the project objective The richness of high-level cognitive and adaptive properties of the brain is reflected in the complexity of its anatomy and (electro)physiology. At the cellular level, evolution privileged for the central nervous system an analog distributed information storage and encoding, by plastic (graded) synapses and by their continuous temporal and spatial integration into firing rates. Beyond all-or-none action potentials, subthreshold synaptic and membrane electric activity in neurons disclose the details of single-neuron computations, neuronal identity and role, information processing and synaptic readout, as well as history-dependent dynamics of excitability and synaptic efficacy. The long-term experimental access to subthreshold activity of many neurons simultaneously, during behaviour and cognition, is then a requirement for the ultimate understanding of brain functions, its reverse engineering, as well as an unexplored alternative for neuroprosthetics.Project BRAINLEAP develops a breakthrough, revolutionary technological approach to explore cognition and plasticity in cortical neuronal networks, and preliminary applies it in vitro and in awake behaving rodents and primates. BRAINLEAP will enable simultaneous, long-term, and independent recording and stimulation of the electrical activity from hundreds of individual mammalian neurons, with a quality that in practice matches the intracellular configuration. By allowing one to record (and stimulate) for very long times, synaptic- and action-potentials from individual neurons, in the context of specific sensorimotor integration tasks, the leap we propose might ultimately shift current paradigms and theories, from spike-centred computation to its underlying subthreshold synaptic potentials computation. Fields of science natural sciencesbiological scienceszoologymammalogyprimatologynatural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineanatomy and morphologymedical and health sciencesbasic medicinephysiologynatural sciencescomputer and information sciencesdata sciencedata processing Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2011.9.1 - Challenging current Thinking Call for proposal FP7-ICT-2011-C See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator UNIVERSITEIT ANTWERPEN EU contribution € 604 960,00 Address PRINSSTRAAT 13 2000 Antwerpen Belgium See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Higher or Secondary Education Establishments Administrative Contact Michele Giugliano (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN Germany EU contribution € 510 106,00 Address MARKWIESENSTRASSE 55 72770 Reutlingen See on map Region Baden-Württemberg Tübingen Reutlingen Activity type Research Organisations Administrative Contact Thomas Schweikert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 330 844,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Célia Farge (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE HEBREW UNIVERSITY OF JERUSALEM Israel EU contribution € 599 084,00 Address EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem See on map Activity type Higher or Secondary Education Establishments Administrative Contact Jane Turner (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Italy EU contribution € 375 600,00 Address Piazzale Aldo Moro 5 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Administrative Contact Cinzia Di Florio (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT VAN AMSTERDAM Participation ended Netherlands EU contribution € 57 756,00 Address SPUI 21 1012WX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Allard de Haart (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data