Ziel
Articulating joint replacements represent a medical market exceeding €14 billion p.a. that is expected to rise as demographics reflect an ageing population. However, faster growth has been seen in the revision market, where prosthetic joints are replaced, than in primary interventions. The major cause of these revisions is that all joint replacements are prone to wear leading to loss of implant function. Further, it has been demonstrated that adverse or extreme loading has a detrimental effect on implant performance. Thus, device failure still occurs too frequently leading to the conclusion that their longevity and reliability must be improved. The premise of this proposal is to realise that wear and corrosion are an inevitable consequence of all implant interfaces within contemporary total joint replacements. To overcome this problem our novel approach is to use silicon nitride coatings in which the combined high wear resistance of this material and solubility of any silicon nitride wear particles released, reduce the overall potential for adverse tissue reactions. In this work a variety of silicon nitride based coatings will be applied to different tribological scenarios related to total hip arthroplasty. The coatings’ suitability in each scenario will be assessed against target profiles. In particular, it is important to consider coating performance within each of these applications under adverse conditions as well as those outlined in internationally utilised standards. To accomplish this, cutting-edge adverse simulation techniques, in vitro assays and animal models will be developed together with a suite of computational assessments to significantly enhance device testing in terms of predicting clinical performance. Data will inform new standards development and enhance current testing scenarios, and will provide 5 European enterprises with a significant market advantage, whilst providing data for a regulatory submission which is aligned with Dir 93/42/EEC.
Wissenschaftliches Gebiet
Programm/Programme
Aufforderung zur Vorschlagseinreichung
FP7-NMP-2012-LARGE-6
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Finanzierungsplan
CP-IP - Large-scale integrating projectKoordinator
LS2 9JT Leeds
Vereinigtes Königreich
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Beteiligte (14)
8092 Zuerich
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751 05 Uppsala
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4657 DULLIKEN
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SK4 3EJ Heaton Mersey
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8006 ZURICH
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8008 ZURICH
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LS9 7TF LEEDS
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78532 Tuttlingen
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9220 Aalborg
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581 83 Linköping
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21079 Hamburg
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21073 Hamburg
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91085 WEISENDORF
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SW7 2AZ LONDON
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