Objective Alzheimer's disease (AD) is characterized by a progressive loss of cognition and memory function, and is defined pathologically by the deposition of amyloid peptide and neurofibrillary tangles and by a marked cortical cholinergic depletion. In the sporadic form of AD, multiple mechanisms can lead the formation of tangles and plaques. Aim: The MEMORIES hypothesis driven project gathers together 8 partners from 5 different countries towards the aim of developing, characterising and validating new animal models that have a real potential for becoming a gold standard in the AD field. Background/rationale: AD is a complex neurodegeneration possibly determined by multiple molecular mechanisms. One recent finding demonstrated that it can be linked to an unbalanced signaling and processing of the pro-NGF/NGF and pro-BDNF/BDNF signalling pathways. Moreover, the involvement of SorLA, a member of a novel family of vacuolar protein sorting 10 protein (Vps10p)-domain receptors, in APP processing and trafficking has been recently suggested. On the basis of these molecular mechanisms, new mouse models will be created. Description: towards the MEMORIES aim, a panel of mouse models will be, using a multidisciplinary approach, produced and analyzed for the presence of neurodegeneration. These mice will express specific antibodies neutralizing TrkA receptors or mutated form of pro-NGF. AD11 anti-NGF, which already represent a good model for sporadic AD, will be crossed to mice in which the human APP or Tau are over-expressed or to mice in which pro-convertases or the TrkB or SorLA receptors are knocked-out. Mice will be analyzed using standardized for neuroanatomy and behavioural analysis. Anticipated output: We anticipate that by blocking different signaling pathways will help in ameliorating the current available experimental mouse models, being also useful to develop new therapeutic tools for this disease and strengthen European competitiveness in the war against'. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2005-2.1.3-7 - Characterisation and use of animal models for neurological and psychiatric diseases Call for proposal FP6-2005-LIFESCIHEALTH-7 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator "RITA LEVI-MONTALCINI" EUROPEAN BRAIN RESEARCH INSTITUTE FOUNDATION EU contribution No data Address Via del Fosso di Fiorano, 64 ROME Italy See on map Links Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all NEURÉVA INC. France EU contribution No data Address 3, rue Trésoriers de la Bourse MONTEPELLIER See on map Links Website Opens in new window Total cost No data MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN Germany EU contribution No data Address Robert-Roessle-Str., 10 740238 BERLIN See on map Links Website Opens in new window Total cost No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution No data Address Meyerhofstrasse 1 HEIDELBERG See on map Links Website Opens in new window Total cost No data HELSINGIN YLIOPISTO Finland EU contribution No data Address Yliopistonkatu 4 HELSINGIN YLIOPISTO, HELSINKI See on map Links Website Opens in new window Total cost No data SWISS INSTITUTE FOR EXPERIMENTAL CANCER RESEARCH Switzerland EU contribution No data Address Chemin des Boveresses 155 EPALINGES See on map Links Website Opens in new window Total cost No data ACIES France EU contribution No data Address 69 rue de la République LYON See on map Links Website Opens in new window Total cost No data NEURONICON APS Denmark EU contribution No data Address c/o Oestjutland Innovation A/S, Gustav Wieds Vej 10 AARHUS C See on map Total cost No data LAY LINE GENOMICS S.P:A Italy EU contribution No data Address Via di Castel Romano 100 ROME See on map Links Website Opens in new window Total cost No data ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE Switzerland EU contribution No data Address Bâtiment CE - 3.316, Station 1 LAUSANNE See on map Links Website Opens in new window Total cost No data PROJETS ET RESEAUX DE RECHERCHE France EU contribution No data Address 69 Rue de la République LYON See on map Total cost No data