Objective Translation of genetic knowledge from the Human Genome into disease-specific therapy for untreatable congenital and acquired diseases is now reality. However, the gene therapy vectors currently used in experimental settings can be developed for safe clinical application only if fundamental problems are solved: ie the limitation of vector dose by attachment targeting and expression control and a decrease of non-specific toxicity. Minimisation of vector immunogenicity (stealthing) is necessary to reduce bloodstream and immune-mediated reduction of effective vector concentration. In the GIANT project, targeting and stealthing of both viral and non-viral vectors will be used to select candidates for testing in Phase I clinical studies. GIANT will concentrate firstly on one uniform model system and disease target (prostate carcinoma) for vector testing standardisation and in vitro, preclinical and clinical vector comparison. We will use a clinically approved vector backbone of adenoviral constructs re-targeted to prostate cancer via surface antigens, and hybrid prostate targeted promoters. The consortium includes a GMP vector production facility and clinical facilities with scientific and ethical permission to carry out human cytotoxic gene therapy trials, guaranteeing the immmediate translation of selected vectors into the clinical testing. The biomaterials obtained will serve to develop new assays for vector distribution, efficacy and monitoring of the immune response against various vector systems. The GIANT participants have a long record of EU-based scientific collaboration and expertise in ethically approved clinical vector generation. The SMEs own international patents on retargeting vectors and target discovery methods, providing a technology platform for further exploration of promising targets and innovative approaches to facilitate treatment of... Fields of science medical and health sciencesclinical medicineoncologyprostate cancermedical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicineimmunologyengineering and technologymaterials engineeringcoating and films Keywords clinical trials gene therapy neoplastic disease non viral retargeting stealthing vector viral Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-1.2.4-1 - Improved gene delivery systems for the therapy of severe acquired diseases Call for proposal FP6-2003-LIFESCIHEALTH-I See other projects for this call Funding Scheme NoE - Network of Excellence Coordinator UNIVERSITY OF YORK EU contribution No data Address HESLINGTON YORK United Kingdom See on map Links Website Opens in new window Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all ERASMUS MC, UNIVERSITY MEDICAL CENTER Netherlands EU contribution No data Address Dr. Molewaterplein 50 1738 ROTTERDAM See on map Links Website Opens in new window Total cost No data UPPSALA UNIVERSITET Sweden EU contribution No data Address Sankt Olofsgatan 10B 256 UPPSALA See on map Links Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address University Offices, Wellington Square OXFORD See on map Links Website Opens in new window Total cost No data LEIDS UNIVERSITAIR MEDISCH CENTRUM Netherlands EU contribution No data Address Albinusdreef 2 9600 LEIDEN See on map Links Website Opens in new window Total cost No data UNIVERSITAT ULM Germany EU contribution No data Address Albert Einstein Allee 29 ULM See on map Links Website Opens in new window Total cost No data INSTITUTE OF MACROMOLECULAR CHEMISTRY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC Czechia EU contribution No data Address Heyrovsky sq. 2 PRAGUE See on map Links Website Opens in new window Total cost No data GOT-A-GENE AB Sweden EU contribution No data Address Stena Center 1B, Holtermansgatan 1B GOTHENBURG See on map Links Website Opens in new window Total cost No data SCURON B.V Netherlands EU contribution No data Address Rochussenstraat 125 25139 ROTTERDAM See on map Links Website Opens in new window Total cost No data PRO-CURE THERAPEUTICS L.T.D United Kingdom EU contribution No data Address Biocentre, York Science Park YORK See on map Links Website Opens in new window Total cost No data LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution No data Address Geschwister-Scholl-Platz 1 MUNICH See on map Links Website Opens in new window Total cost No data UNIVERSITE DE STRASBOURG France EU contribution No data Address 4 rue Blaise Pascal STRASBOURG See on map Links Website Opens in new window Total cost No data POLYPLUS TRANSFECTION France EU contribution No data Address Bioparc, Boulevard Sebastien Brant BP90018 ILLKIRCH See on map Links Website Opens in new window Total cost No data HYBRID BIOSYSTEMS LTD. United Kingdom EU contribution No data Address 77 Heyford Park, Oxfordshire OXFORD See on map Links Website Opens in new window Total cost No data