Objective GenOSept is a specific targeted research project (STREP) which uses a multidisciplinary fundamental genomics approach (gene expression, structural genomics, population genetics) to examine genetic predisposition to sepsis. Sepsis (life-threatening infection) is a major public health problem throughout Europe. In the USA in 1995 it cost $17 billion to treat 751,000 patients with severe sepsis, of whom 28.6% died. The Center for Disease Control suggests that sepsis-attributable mortality rates are rising. We hypothesize that susceptibility to expensive new treatments, and fatal outcomes from severe sepsis, are in part, genetically determined. GenOSept work packages will test this hypothesis using the following approach. We will use gene expression studies to define novel candidate genes including those controlling programmed cell death. The novel candidate genes so identified will then be analysed in subsequent epidemiologic studies of genetic predisposition to sepsis-related mortality and morbidity in European intensive care units. The European Society of Intensive Care Medicine (ESICM) will co-ordinate a consortium of leading experts in sepsis, genomics, genetic epidemiology, biometrics and genetic high-throughput genotyping to link this new science to patient-centred outcomes. GenOSept will provide important data on gender-related mortality and morbidity. It will have a major impact on diagnosis and treatment of European sepsis patients in subsequent therapeutic trials by targeting risk subpopulations and focussing expensive new treatments. GenOSept will standardise protocols for genotyping, facilitate application of new knowledge in functional and structural genomics, harmonize high-throughput genotyping and quality control between major European centres, and contribute to reducing sepsis-related mortality in European health care. Fields of science social sciencessociologydemographymortalitymedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesclinical medicinecritical care medicinenatural sciencesbiological sciencesgeneticsgenomes Keywords Intensive Care Medicine epidemiology genetic predisposition genetic testing mortality sepsis Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Call for proposal FP6-2003-LIFESCIHEALTH-I See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator EUROPEAN SOCIETY OF INTENSIVE CARE MEDICINE EU contribution No data Address Avenue Joseph Wybran 40 BRUSSELS Belgium See on map Links Website Opens in new window Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÂT BONN Germany EU contribution No data Address Regina-Pacis-Weg 3 BONN See on map Links Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE France EU contribution No data Address 2 ter rue d'Alésia PARIS See on map Links Website Opens in new window Total cost No data CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address University Offices, Wellington Square OXFORD See on map Links Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI TORINO Italy EU contribution No data Address Via Verdi 8 TORINO See on map Links Website Opens in new window Total cost No data UNIVERSITY ROVIRA & VIRGILI - HOSPITAL UNIVERSITARI JOAN XXIII Spain EU contribution No data Address Carrer Dr Mallafre Guasch 4 TARRAGONA See on map Total cost No data GSF NATIONAL RESEARCH CENTER FOR ENVIRONMENT AND HEALTH Germany EU contribution No data Address Ingolstädter Landstr. 1 1129 NEUHERBERG See on map Links Website Opens in new window Total cost No data HADASSAH MEDICAL ORGANISATION Israel EU contribution No data Address Kiryat Hadasah 12000 JERUSALEM See on map Total cost No data SIRS-LAB GMBH Germany EU contribution No data Address Winzerlaer Strasse 2 JENA See on map Links Website Opens in new window Total cost No data UNIVERSITY ULM, MEDICAL FACULTY Germany EU contribution No data Address Steinhövelstrasse 5 ULM See on map Links Website Opens in new window Total cost No data KLINIKUM DER FRIEDRICH-SCHILLER-UNIVERSITÄT JENA Germany EU contribution No data Address Bachstr. 18 JENA See on map Links Website Opens in new window Total cost No data MASARYK UNIVERSITY BRNO, MEDICAL FACULTY Czechia EU contribution No data Address Zerotinovo nam.9 BRNO See on map Links Website Opens in new window Total cost No data NATIONAL MEDICAL CENTER Hungary EU contribution No data Address Szabolcs u. 33-35 BUDAPEST See on map Links Website Opens in new window Total cost No data TARTU UNIVERSITY CLINICS Estonia EU contribution No data Address L. Puusepa 8 TARTU See on map Links Website Opens in new window Total cost No data