European Commission logo
italiano italiano
CORDIS - Risultati della ricerca dell’UE
CORDIS
Contenuto archiviato il 2024-05-29

Analyzing the functions of AP-1 in liver carcinogenesis

Obiettivo

Hepatocellular carcinoma (HCC) causes about 500,000 deaths worldwide each year and is the leading cause of cancer mortality in some parts of the world. Although the pathogens for HOC are quite clear, the molecular mechanisms through which they induce HOC development still need to be clarified. AP-1 genes encode transcription factors, which possibly play important roles in many cancers, including HOC.

Until now, little is known about their functions in liver carcinogenesis. In this respect, I will investigate AP-1 functions in genotoxiccarcinogen induced HCC using conditional knock-out mice. This study will focus on c-Jun, c-Fos and p53pathways and their interactive functions in liver cancer, especially in the early stages of carcinogenesis. Molecules responsible f or dysregulated apoptosis and proliferation will be identified by molecular, immunohistological and micro-array analyses.

This project will uncover novel insights into the molecular mechanisms involved in HCC, which may provide new avenues for the development of diagnostic and drug targets in the future.

Invito a presentare proposte

FP6-2002-MOBILITY-7
Vedi altri progetti per questo bando

Coordinatore

RESEARCH INSTITUTE FOR MOLECULAR PATHOLOGY
Contributo UE
Nessun dato
Indirizzo
Dr Bohr-Gasse 7
VIENNA
Austria

Mostra sulla mappa

Collegamenti
Costo totale
Nessun dato