Objective The Fibro-Targets project is a multi-disciplinary 4 years program involving 10 partners ambitioning “the identification, characterisation and validation of in vitro and in vivo models of novel therapeutically relevant targets” for myocardial interstitial fibrosis (MIF) in heart failure. The project is based on the hypothesis that the intervention on novel fibrosis-related targets involved in the processes of fibroblast differentiation to myofibroblasts, the predominance of collagen synthesis over degradation and/or collagen maturation may allow for interstitial repair, thus providing a new strategy for the prevention and treatment of adverse cardiac remodeling involved in the transition to and the progression of heart failure. From a large body of existing multi-omics, literature data and previous hypothesis-driven research conducted by members of the consortium, a number of specific extracellular and intracellular targets have been identified whose involvement in MIF is beginning to be understood and that may be targeted by specific therapies.The specific aims of the Fibro-Targets are:(i) To provide further evidence on the mechanisms of action of the above targets(ii) To validate experimentally that new anti-fibrotic strategies can be developed based on the above targets(iii) To approach the potential clinical scenario of the above targets for HF therapyTo reach these aims the following studies will be performed:(i) Observational and interventional experimental studies in already existing and/or de novo generated appropriate in vitro and in vivo models.(ii) Clinical studies, stratifying large scale populations of patients available to the consortium, at risk to develop HF and likely to be responsive to specific novel and/or exiting anti-fibrotic therapies. The stratification will be based on specific “fibrogenetic” phenotypic profiles using multi-panel imaging and circulating markers descriptive of mechanisms involving the proposed novel targets. Fields of science medical and health sciencesclinical medicinecardiology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.4.2-1 - Discovery research to reveal novel targets for cardiovascular disease treatment Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE EU contribution € 1 050 010,00 Address RUE DE TOLBIAC 101 75654 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Marie-Ange Luc (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSERM TRANSFERT SA France EU contribution € 400 000,00 Address 10 RUE D'ORADOUR-SUR-GLANE - PARISANTE CAMPUS 75015 PARIS See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Louis Jammayrac (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA Spain EU contribution € 600 000,00 Address AVENIDA DE PIO XII 55 31008 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Research Organisations Administrative Contact Andrew Solomon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland EU contribution € 200 000,00 Address BELFIELD 4 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Administrative Contact Donal Doolan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT MAASTRICHT Netherlands EU contribution € 500 000,00 Address MINDERBROEDERSBERG 4 6200 MD Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Higher or Secondary Education Establishments Administrative Contact Rob Van Der Zander (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE HOCHSCHULE HANNOVER Germany EU contribution € 500 000,00 Address Carl-Neuberg-Strasse 1 30625 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Higher or Secondary Education Establishments Administrative Contact Frank Dittrich (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 680 000,00 Address SPITALGASSE 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Gerald Maurer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GREENPHARMA S.A. France EU contribution € 390 000,00 Address Allée du Titane 3 45100 Orléans See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Quoc Tuan Do (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FIRALIS France EU contribution € 960 000,00 Address RUE DU FORT 35 68330 Huningue See on map Region Grand Est Alsace Haut-Rhin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Regine Will (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Innovative Technologies in Biological Systems Spain EU contribution € 450 000,00 Address PARQUE TECNOLOGICO DE BIZKAIA 502-1 48160 Derio See on map Region Noreste País Vasco Bizkaia Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Isbaal Ramos (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION PUBLICA MIGUEL SERVET Spain EU contribution € 269 990,00 Address CALLE IRUNLARREA 3 CENTRO INVESTIGACION BIOMEDICA RECINTO COMPLEJO HOSPITALARIO DE NAVARRA 31008 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Research Organisations Administrative Contact Maria Soledad Fragoso (Ms.) Links Contact the organisation Opens in new window Total cost No data