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Novel combination of biopolymers and manufacturing technologies for production of a peripheral nerve implant containing an internal aligned channels array

Objective

Peripheral nerves are basic communication structures guiding motor and sensitive information from CNS to effector or receptor units. Severe nerve injuries include axon bundles section and Schawnn cells destruction, which results in loss of motion control and sensorial perception. After the lesion, cells present in damaged nerves activate spontaneously self-regeneration programs that might facilitate further treatment. Nerve autograft is the “gold standard” surgical intervention that demands autologous tissue extraction and corresponding function loss. The goal of the project is the validation of biomaterials structural plasticity and those compatible manufacturing technologies that will enable the generation of a tubular structure containing an intraluminal microstructure based on an array of aligned channels or fibers. The regenerative properties of this prototype will be also validated in vivo in a sciatic nerve section animal model. This project proposal will take advantage of partners’ experience in the design of medical devices composed of natural and synthetic biomaterials and in scaled-up production mechanization technologies for the generation of the most effective peripheral nerve implant.

Call for proposal

FP7-NMP-2013-SME-7
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Coordinator

FUNDACION TEKNIKER
EU contribution
€ 663 889,00
Address
CALLE INAKI GOENAGA 5
20600 Eibar Guipuzcoa
Spain

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Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
Administrative Contact
Saioa Mondragon (Ms.)
Links
Total cost
No data

Participants (7)