Objective Standard of care strategies for the treatment of cancer still relies heavily on non-specific radiation- and chemotherapy. They are commonly associated with severe toxicities and in many cases only offer limited benefit for the patient. The targeted delivery of radionuclides, cytotoxic drugs and proinflammatory cytokines into malignant tissue, on the other hand, can markedly improve the therapeutic index and overall efficacy of such substances. Whilst monoclonal antibodies are the most widely used delivery vehicles to date, we believe that small molecule ligands will offer improved targeting properties. Most importantly, depth of tumour penetration and tumour-to-blood distribution ratio after injection should be significantly superior. We therefore propose to systematically investigate the targeting performance of somatostatin receptor non-internalizing ligands for the targeted delivery of cytokines into somatostatin receptor-overexpressing tumours. This project aims at (1) developing a general chemical approach for building safe small molecule cytokine conjugates (SMCC) (2) demonstrate that a somatostatin antagonist, non-internalizing ligand can selectively accumulate in somatostatin receptor-overexpressing cancers and (3) when site-specifically conjugated to proinflammatory interleukin-12, these novel SMCC are highly effective for the treatment of acute myeloid leukaemia (AML). Fields of science medical and health sciencesclinical medicineoncologyleukemianatural scienceschemical sciencesnuclear chemistryradiation chemistry Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Call for proposal FP7-PEOPLE-2013-IEF See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE EU contribution € 309 235,20 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge United Kingdom See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Renata Schaeffer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
