Objective Despite the increasing number and multivariate nature of anthropogenic and natural stress, ecological research has primarily focused upon the effects of a single stressor on specific species or ecosystems. However, understanding relationships among multiple stressors – and the mechanisms underlying stressor interactions – is crucial for solving environmental problems. The proposed GF will address this topic by studying multiple stressors in a model system, filling knowledge gaps on the effects of simultaneous low temperature stress, pathogens and chemical challenges on animals. The proposed work combines theory and state-of-the-art methods from ecophysiology, ecotoxicology, immunology, evolutionary ecology and molecular biology, and has direct applications in environmental management and protection. The project uses insects as models, since they drive important ecological processes and are under high pressure from anthropogenic influences. Combinations of stressors will be explored under controlled conditions in a comparative multi-species approach in the fly genus Drosophila. The simultaneous application of the chosen stressors has not previously been comprehensively investigated, in spite of their relevance for management of both harmful and beneficial insects globally. The project has three aims: 1) to define the scope of tolerance against each stressor in isolation for each Drosophila species; 2) to identify potential interactions between the stressors and explore the predictability of the joint effects on performance and survival; 3) to investigate mechanistic underpinnings of possible stressor interactions. This project will establish a framework that allows me to extend my research deeper into the field and set the stage for a wider understanding of stress-related biology. Fields of science natural sciencesearth and related environmental sciencesenvironmental sciencespollutionnatural sciencesbiological sciencesecologyevolutionary ecologynatural sciencesbiological sciencesecologyecosystemsnatural sciencesbiological scienceszoologyentomologynatural sciencesbiological sciencesmolecular biology Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2014-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF) Call for proposal H2020-MSCA-IF-2014 See other projects for this call Funding Scheme MSCA-IF-GF - Global Fellowships Coordinator ITA-SUOMEN YLIOPISTO Net EU contribution € 235 285,20 Address YLIOPISTONRANTA 8 70211 KUOPIO Finland See on map Region Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 235 285,20 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. THE UNIVERSITY OF WESTERN ONTARIO Canada Net EU contribution € 0,00 Address RICHMOND STREET NORD - SUITE 2 1151 N6A 3K7 Ontario -London See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 145 622,40