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In Vivo Spectral Photon Counting CT Molecular Imaging in Cardio- and Neuro-Vascular Diseases

Objective

The objective of the SPCCT project is to develop and validate a widely accessible, new quantitative and analytical in vivo imaging technology combining Spectral Photon Counting CT and contrast agents, to accurately and early detect, characterize and monitor neurovascular and cardiovascular disease. Spectral Photon Counting Computed Tomography (SPCCT) is a new imaging modality, currently in development, with a totally new type of detection chain designed to provide high count-rate capabilities while offering energy discrimination with high spatial resolution of 200µm. Based on this discrimination, SPCCT can detect and quantify accurately a large variety of atoms (including Gadolinium, Gold, Bismuth…) by using the K-edge technique. SPCCT, by a more accurate, less invasive (in comparison with IVUS and coronary angiography) and reliable evaluation of vascular inflammation will allow earlier disease diagnosis such as plaque inflammation before rupture, leading to improved clinical decisions and outcomes. This will be achievable with a high spatial resolution combined to the newly developed vascular inflammation specific contrast agent detected with high quality K-edge technique that can only be provided by a multi-spectral X-ray system. The project will therefore provide a complete tool (acquisition system and specific probes) dedicated to CV imaging. It will finally contribute to: Improved early diagnosis of atherosclerosis, prevention of acute event (MI, stroke) and personalized preventive treatment; Improved management of patient presenting with an acute CV event and clinical validation of treatment efficiency; Sustainability and harmonization of healthcare systems, as costly disorders of heart failure and stroke-related disability would be better prevented and efficiently treated; Economic growth in the EU diagnostics sector, through the development of new targeted contrast materials for SPCCT by SMEs.

Field of science

  • /medical and health sciences/basic medicine/neurology/stroke
  • /social sciences/sociology/social problems/ageism
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /social sciences/other social sciences/social sciences interdisciplinary/sustainable development
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases/arteriosclerosis
  • /medical and health sciences/clinical medicine/radiology/medical imaging/computed tomography

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 142 356,56

Participants (10)

PHILIPS GMBH
Germany
EU contribution
€ 442 375
Address
Rontgenstrasse 22
22335 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PHILIPS MEDICAL SYSTEMS TECHNOLOGIES LTD
Israel
EU contribution
€ 1 505 000
Address
Scientific Industries Center Haifa 31004 Isena Raodnich
325 Haifa Haifa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MATHYM
France
EU contribution
€ 269 062,50
Address
22 Rue Des Aulnes
69410 Champagne-au-mont-d'or
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 535 500
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
VOXCAN
France
EU contribution
€ 392 201,25
Address
1, Avenue Bourgelat
69280 Marcy L'etoile
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ERASMUS UNIVERSITEIT ROTTERDAM
Netherlands
EU contribution
€ 405 478,75
Address
Burgemeester Oudlaan 50
3062 PA Rotterdam
Activity type
Higher or Secondary Education Establishments
CLINIQUES UNIVERSITAIRES SAINT-LUC
Belgium
EU contribution
€ 96 720,94
Address
Avenue Hippocrate 10
1200 Bruxelles
Activity type
Research Organisations
LYON INGENIERIE PROJETS
France
EU contribution
€ 229 750
Address
Bd Du 11 Novembre 1918 43 L Atrium
69616 Villeurbanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 331 968,75
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
BRACCO IMAGING SPA
Italy
EU contribution
€ 91 250
Address
Via Egidio Folli 50
20134 Milan
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)