Objective In eukaryotes, SUMO (Small Ubiquitin Modifier) conjugation to proteins is an essential process that regulates many aspects of cell biology. Defects in SUMO conjugation have been associated to cancer, neurodegenerative diseases and others, raising a great interest in developing novel drugs for inhibiting SUMO conjugation.Specifically, recent reports have pointed to a high dependency on an active SUMO conjugation by Myc-overexpressing cancers. Consequently, SUMO conjugation has become a non-oncogene addiction target of special relevance since the oncogenic Myc is nondruggable. Based on the results obtained by our group, we have developed a novel assay for identifying efficient SUMO conjugation inhibitors, which could lead to the identification of novel therapeutic drugs.The main outcome that we expect to obtain from this project is the identification of a SUMOylation inhibitor that will be patent protected. Initial steps towards the valorization of the identified product will be taken, and available commercialization opportunities will be carefully analyzed for entering into the next steps of drug development, including preclinical and clinical studies.The fact that SUMOylation may be a key element in almost 70% of cancer types due to its involvement in the Myc pathway makes the search for hit drug candidates an enterprise worth taking, which could benefit millions of people worldwide. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencescell biologymedical and health sciencesclinical medicineoncology Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-PoC-2014 - ERC Proof of Concept Grant Call for proposal ERC-2014-PoC See other projects for this call Funding Scheme ERC-POC - Proof of Concept Grant Host institution CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB Net EU contribution € 150 000,00 Address PARC DE RECERCA DE L UAB CAMPUS UAB EDIFICI CRAG BELLATERRA 08193 Cerdanyola Del Valles Spain See on map Region Este Cataluña Barcelona Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 150 000,00 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB Spain Net EU contribution € 150 000,00 Address PARC DE RECERCA DE L UAB CAMPUS UAB EDIFICI CRAG BELLATERRA 08193 Cerdanyola Del Valles See on map Region Este Cataluña Barcelona Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 150 000,00