Objective As for adults, chronic liver disease is children is a major, rapidly growing health problem. The main causal factor is obesity, leading to fatty liver disease and non-alcoholic steatohepatitis. Inadequately treated children with liver disease will impose a disproportionate life-long burden on a nation’s healthcare system. In the EU, one third of adolescents is overweight/obese. Current techniques to diagnose and monitor liver disease in children are poor, insensitive or invasive. Liver biopsy is painful, costly, and samples only a tiny fraction of the liver. Perspectum Diagnostics is a University of Oxford spin-out founded by world-leading clinical and engineering experts in MRI. They have developed a quick, non-invasive MRI test that measures accurately the main features of liver pathology. Clinical trials in adults show excellent diagnostic performance and reproducibility. Perspectum’s first product, LiverMultiScan (LMS), is CE-marked for diagnosis of adult liver disease. We propose substantial modification of LMS for liver disease in children/adolescents. This requires adaptation and optimization of the methods in LMS, not least definition of thresholds and grading of disease, and analysis/presentation of results. A multicentre clinical trial is needed to obtain solid clinical evidence of diagnostic efficacy and cost-effectiveness of Paediatric LMS. We will develop a study design with a clinical trials unit; establish a network of EU clinical sites; ensure recruitment and technical feasibility at each site; cost the clinical study; establish economic viability; obtain more precise estimates of market size and growth rates, as well as the economic benefit to users. Paediatric LMS can become the standard test for assessing chronic liver disease in children, presenting not only a huge economic opportunity, but also the chance to greatly improve liver health in EU children. We will deliver a business plan for a subsequent phase 2 application. Fields of science medical and health sciencesbasic medicinepathologymedical and health sciencesclinical medicinehepatologymedical and health sciencesclinical medicinepaediatricsengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingmedical and health scienceshealth sciencesnutritionobesity Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.3. - Treating and managing disease Topic(s) PHC-12-2014-1 - Clinical research for the validation of biomarkers and/or diagnostic medical devices Call for proposal H2020-SMEInst-2014-2015 See other projects for this call Sub call H2020-SMEINST-1-2014 Funding Scheme SME-1 - SME instrument phase 1 Coordinator PERSPECTUM LTD Net EU contribution € 50 000,00 Address GEMINI ONE, 5520 JOHN SMITH DRIVE OXFORD BUSINESS PARK SOUTH OX4 2LL Oxford United Kingdom See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 71 429,00
