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European AIDS Vaccine Initiative 2020

Objective

HIV-1 is responsible for a global pandemic of 35 million people, and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, while a therapeutic vaccine may help mitigate the clinical course of disease and lead to strategies of viral eradication. However despite 30 years of research, we do not have a vaccine capable of protecting from HIV-1 infection or impacting on disease progression. This in part represents the challenge of identifying immunogens and vaccine modalities with reduced risk of failure in late stage development. To overcome this bottleneck some of the most competitive research groups in vaccine discovery from European public institutions and biotechs from 9 EU countries together with top Australian and Canadian groups and US collaborators, have agreed to join forces in EAVI, providing a pool of international expertise at the highest level. EAVI2020 will provide a platform for the discovery and selection of several new, diverse and novel preventive and/or therapeutic vaccine candidates for HIV/AIDS. Emphasis will be placed on early rapid, iterative, small Experimental medicine (EM) human vaccine studies to select and refine the best immunogens, adjuvants, vectors, homologous and heterologous prime–boost schedules, and determine the impact of host factors such as gender and genetics. Animal models will be used to complement human studies, and to select novel immunization technologies to be advanced to the clinic. To shift the “risk curve” in product development we will develop innovative risk prediction methods, specifically designed to reduce the risk associated with late stage preventive or therapeutic vaccine failure, increasing the chance of discovery of an effective vaccine.

Field of science

  • /natural sciences/biological sciences/genetics and heredity

Call for proposal

H2020-PHC-2015-single-stage_RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 6 118 355,92

Participants (26)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 2 300 415
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 1 140 062,50
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA
Spain
EU contribution
€ 1 998 031,25
Address
Carretera De Canyet
08916 Barcelona
Activity type
Research Organisations
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 389 700
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH
Austria
EU contribution
€ 3 449 000
Address
Donaustrasse 99
3400 Klosterneuburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA

Participation ended

Spain
EU contribution
€ 437 869,67
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 571 500
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 390 635
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
OSPEDALE SAN RAFFAELE SRL
Italy
EU contribution
€ 669 938,75
Address
Via Olgettina 60
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE GRENOBLE ALPES

Participation ended

France
EU contribution
€ 0
Address
621, Avenue Centrale
38401 Saint Martin D'heres
Activity type
Higher or Secondary Education Establishments
UNIVERSITE GRENOBLE ALPES

Participation ended

France
EU contribution
€ 0
Address
621 Avenue Centrale
38058 Grenoble
Activity type
Higher or Secondary Education Establishments
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 190 612,50
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 895 561,25
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 564 021
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF WESTERN ONTARIO
Canada
EU contribution
€ 0
Address
Richmond Street Nord - Suite 2 1151
N6A 3K7 Ontario -London
Activity type
Higher or Secondary Education Establishments
NEMZETI ELELMISZERLANC-BIZTONSAGI HIVATAL
Hungary
EU contribution
€ 211 298,75
Address
Keleti Karoly Utca 24
1024 Budapest
Activity type
Other
LUDWIG BOLTZMANN GESELLSCHAFT GMBH

Participation ended

Austria
EU contribution
€ 201 250
Address
Nussdorfer Strasse 64 6 Stock
1090 Wien
Activity type
Research Organisations
BIONTECH RNA PHARMACEUTICALS GMBH
Germany
EU contribution
€ 371 375
Address
An Der Goldgrube 12
55131 Mainz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUTO DE SALUD CARLOS III
Spain
EU contribution
€ 403 828,75
Address
Monforte De Lemos 5
28029 Madrid
Activity type
Research Organisations
STICHTING INTERNATIONAL AIDS VACCINE INITIATIVE THE NETHERLANDS

Participation ended

Netherlands
EU contribution
€ 0
Address
Van Diemenstraat 20, 200 Unit 48
1013 NH Amsterdam
Activity type
Other
UNIVERSITY OF MELBOURNE
Australia
EU contribution
€ 0
Address
Parkvilleoffice Of The Vice Chancellor
3010 Melbourne
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF NEW SOUTH WALES
Australia
EU contribution
€ 0
Address
Anzac Parade
2052 Sydney
Activity type
Higher or Secondary Education Establishments
GENOME RESEARCH LIMITED

Participation ended

United Kingdom
EU contribution
€ 0
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
INTERNATIONAL AIDS VACCINE INITIATIVE INC
United States
EU contribution
€ 626 000
Address
125 Broad Street, 9Th Floor
10004 New York
Activity type
Research Organisations
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 210 343,75
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 195 315,66
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations