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Atomic Force Microscopy for Molecular Structure Elucidation

Objective

Molecular structure elucidation is of great importance in synthetic chemistry, pharmacy, life sciences, energy and environmental sciences, and technology applications. To date structure elucidation by atomic force microscopy (AFM) has been demonstrated for a few, small and mainly planar molecules. In this project high-risk, high-impact scientific questions will be solved using structure elucidation with the AFM employing a novel tool and novel methodologies.

A combined low-temperature scanning tunneling microscope/atomic force microscope (LT-STM/AFM) with high throughput and in situ electrospray deposition method will be developed. Chemical resolution will be achieved by novel measurement techniques, in particular the usage of different and novel tip functionalizations and combination with Kelvin probe force microscopy. Elements will be identified using substructure recognition provided by a database that will be erected and by refined theory and simulations.

The developed tools and techniques will be applied to molecules of increasing fragility, complexity, size, and three-dimensionality. In particular samples that are challenging to characterize with conventional methods will be studied. Complex molecular mixtures will be investigated molecule-by-molecule taking advantage of the single-molecule sensitivity. The absolute stereochemistry of molecules will be determined, resolving molecules with multiple stereocenters. The operation of single molecular machines as nanocars and molecular gears will be investigated. Reactive intermediates generated with atomic manipulation will be characterized and their on-surface reactivity will be studied by AFM.

Field of science

  • /natural sciences/earth and related environmental sciences/environmental sciences
  • /natural sciences/earth and related environmental sciences
  • /engineering and technology/chemical engineering
  • /natural sciences/chemical sciences
  • /natural sciences/physical sciences/molecular and chemical physics

Call for proposal

ERC-2015-CoG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant
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Host institution

IBM RESEARCH GMBH
Address
Saeumerstrasse 4
8803 Rueschlikon
Switzerland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 2 000 000

Beneficiaries (1)

IBM RESEARCH GMBH
Switzerland
EU contribution
€ 2 000 000
Address
Saeumerstrasse 4
8803 Rueschlikon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)