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MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs

Objective

The concept behind MOZART is to develop a library of inorganic nanomatrices to be used as smart platforms for effective, non-invasive and highly targeted therapies. MOZART will address, as proof of concept, nanomatrices to treat delayed bone healing and non-healing chronic skin wounds, which are both characterised by an inflammation and often infection. Mesoporous therapeutic glasses (MTGs), doped with selected ions (e.g. Ag+, Li+, Cu2+, Sr2+, Ce3+, B3+) and having nanopores of adjustable size within 2-50 nm, will be synthesised and then loaded with the chosen payload. Ordered mesoporous carbons (OMCs) will also be manufactured to host a wide range of biomolecules and higher payload. As in an orchestra, where the integration among the different participants allows a harmonious symphony to be created, in MOZART the synergistic release of ions and drugs will be directed to achieve a radically improved therapeutic effect. The exploitation of the response of self-immolative polymer coatings upon pH changes will be used as an elegant and effective way for triggering the payload release. The (coated) nanomatrices will be incorporated in a thermosensitive gel that is liquid at room temperature and undergoes sol-gel transition in the physiological environment. These gels are perfect candidates to develop non-invasive procedures to introduce MOZART nanomatrices to the pathological site and keep them in place for the required time. Clinical and societal impacts of MOZART will be enormous, considering the extraordinarily high number of pathological cases potentially involved. Only in EU, 350 000 patients per year are affected by non-union bone fractures and 2.2 million people suffer from chronic wounds. We expect that MOZART approaches will significantly reduce the healing time of non-union bone fractures (within 4 months vs. a minimum of 12 months) and will allow at least 50% of people suffering from chronic wounds to heal fully.

Field of science

  • /engineering and technology/materials engineering/coating and films
  • /natural sciences/biological sciences/biochemistry/biomolecules

Call for proposal

H2020-NMP-PILOTS-2015
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

POLITECNICO DI TORINO
Address
Corso Duca Degli Abruzzi 24
10129 Torino
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 925 000

Participants (10)

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany
EU contribution
€ 381 975
Address
Schlossplatz 4
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 265 000
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""
Greece
EU contribution
€ 369 300
Address
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi
Activity type
Research Organisations
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 709 000
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 500 930
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
NANOLITH SVERIGE AB
Sweden
EU contribution
€ 321 898,75
Address
Ferievagen 15
168 41 Bromma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOBIL BIO RICERCHE SRL
Italy
EU contribution
€ 322 500
Address
Via Della Stella 64
25062 Concesio
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASHLAND SPECIALTIES IRELAND LIMITED
Ireland
EU contribution
€ 536 875
Address
Synergy Centre, Laboratory A, Technological University Dublin (Tu Dublin), Tallaght
D24 A386 Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CELLOGIC GMBH
Germany
EU contribution
€ 93 750
Address
Niedstrasse 21
12159 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DELSITECH OY
Finland
EU contribution
€ 225 000
Address
Itainen Pitkakatu 4 B
20520 Turku
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)