Objective Counteracting high attrition rates in oncology drug development and providing optimal therapeutic management of cancer patients require preclinical models that properly recapitulate the complexity and diversity of human tumours. Patient-derived tumour xenografts (PDXs), established by transplanting tumour fragments into immunodeficient mice, are being widely embraced by the scientific community as preclinical tools for target and biomarker discovery. The overall goal of EDIReX is to establish a cutting-edge European infrastructure offering Trans-national Access (TA) of PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of efficacy studies. To ensure interoperability in services, TA initiatives will be backed by Networking Activities (NAs); these will be mainly centred around the establishment of standard procedures for PDX quality control, long-term storage and therapeutic mouse trials. NAs will also entail the adoption of shared ethics parameters for animal experimentation, the wide dissemination of services and project results, and the design of plans to ensure sustainability of the infrastructure. User outreach will be maximised by Joint Research Activities through a three-pronged approach: i) the implementation of a public Data Portal for efficient and user-friendly query and visualisation of clinical, molecular and pharmacological annotation of the models; ii) a cross-validation mouse trial to harmonise inter-laboratory procedures, thus improving the quality and reliability of service provision; and iii) the development of exploratory, more advanced PDX-based preclinical platforms, such as orthotopic and humanised models and in vitro PDX-derived cells. Capitalising on all these assets, EDIReX will contribute to structuring the European Research Area and global cooperation of research infrastructures. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicineoncology Keywords preclinical and translational oncology xenograft biobank joint management of distributed infrastructure standards repository trans-national access research dissemination training Programme(s) H2020-EU.1.4. - EXCELLENT SCIENCE - Research Infrastructures Main Programme H2020-EU.1.4.1.2. - Integrating and opening existing national and regional research infrastructures of European interest Topic(s) INFRAIA-02-2017 - Integrating Activities for Starting Communities Call for proposal H2020-INFRAIA-2016-2017 See other projects for this call Sub call H2020-INFRAIA-2017-1-two-stage Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSITA DEGLI STUDI DI TORINO Net EU contribution € 596 143,85 Address VIA GIUSEPPE VERDI 8 10124 Torino Italy See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 596 143,85 Participants (18) Sort alphabetically Sort by Net EU contribution Expand all Collapse all KATHOLIEKE UNIVERSITEIT LEUVEN Belgium Net EU contribution € 403 387,50 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 403 387,50 THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom Net EU contribution € 251 133,63 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 251 133,63 INSTITUT CURIE France Net EU contribution € 421 385,00 Address RUE D ULM 26 75231 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 421 385,00 FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO) Spain Net EU contribution € 517 595,00 Address CALLE NAZARET 115-117 08035 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 517 595,00 STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Netherlands Net EU contribution € 429 325,00 Address PLESMANLAAN 121 1066 CX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 429 325,00 Masarykova univerzita Czechia Net EU contribution € 448 250,00 Address Zerotinovo namesti 9 601 77 Brno See on map Region Česko Jihovýchod Jihomoravský kraj Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 448 250,00 EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany Net EU contribution € 380 225,85 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 380 225,85 BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC) Austria Net EU contribution € 70 558,75 Address NEUE STIFTINGTALSTRASSE 2/B/6 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 70 558,75 ROYAL COLLEGE OF SURGEONS IN IRELAND Ireland Net EU contribution € 200 374,70 Address ST STEPHEN'S GREEN 123 2 Dublin See on map Region Ireland Northern and Western Border Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 200 374,70 INSTITUT CATALA D'ONCOLOGIA Spain Net EU contribution € 48 565,73 Address AV GRAN VIA DE L'HOSPITALET 199-203 08908 L'HOSPITALET DEL LLOBREGAT See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 48 565,73 THE UNIVERSITY OF MANCHESTER United Kingdom Net EU contribution € 51 250,00 Address OXFORD ROAD M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 51 250,00 ACADEMISCH ZIEKENHUIS GRONINGEN Netherlands Net EU contribution € 214 256,25 Address HANZEPLEIN 1 9713 GZ Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 214 256,25 OSLO UNIVERSITETSSYKEHUS HF Norway Net EU contribution € 96 971,25 Address KIRKEVEIEN 166 TARNBYGGET 0450 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 96 971,25 ISTITUTO EUROPEO DI ONCOLOGIA SRL Italy Net EU contribution € 211 693,13 Address VIA FILODRAMMATICI 10 20121 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 211 693,13 HOSPITAL UNIVERSITARIO DE FUENLABRADA Spain Net EU contribution € 16 037,50 Address CALLE DEL MOLINO 2 28942 Fuenlabrada See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 16 037,50 KAIROS3D SRL Italy Net EU contribution € 249 675,00 Address VIA AGOSTINO DA MONTEFELTRO 2 10134 Torino See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Ovest Piemonte Torino Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 249 675,00 CROWN BIOSCIENCE NETHERLANDS BV Netherlands Net EU contribution € 254 936,98 Address YALELAAN 42 3512 KC Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 254 936,98 SEEDING SCIENCE France Net EU contribution € 294 433,63 Address 19 RUE DE LA MARE 75020 Paris See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 294 433,63