Project description DEENESFRITPL Novel single-molecule bioelectronic system for clinical biomarker detection Enabling the detection of several biomarkers simultaneously will improve the sensitivity of tests and diagnostic conclusions. Moreover, biomarkers should be detected with the highest possible analytical sensitivity as they are typically not present in cell populations, and one single molecule can reveal the onset of a pathological state. The EU-funded SiMBiT project aims to develop a bioelectronic system to enable single-molecule detection of both proteins and DNA biomarkers. The objective is the development of a lab-based and cost-effective portable multiplexing array prototype that produces fast results. SiMBiT will be employed for the early detection of human pancreatic neoplasms, performing simultaneous analysis of genomic and protein markers with a minimal sample volume. Show the project objective Hide the project objective Objective Digitizing biomarkers analysis by quantifying them at the single-molecule level is the new frontier for advancing the science of precision health. The SiMBiT project will develop a bio-electronic smart system leveraging on an existing lab-based proof-of-concept that can perform single-molecule detection of both proteins and DNA bio-markers. Specifically, the SiMBiT activities will develop the lab-based device into a cost-effective portable multiplexing array prototype that integrates, with a modular approach, novel materials and standard components/interfaces. The SiMBiT platform exhibits enhanced sensing capabilities: specificity towards both genomic and protein markers along with single-molecule detection limits and time-to-results within two hours. This makes the SiMBiT prototype the world best performing bio-electronic sensing system ever. SiMBiT will reach these ambitious goals with a multidisciplinary research effort involving device-physicists, analytical-chemists, bio-chemists, clinicians, electronic- and system-engineers. The platform is also single-use and cost-effective and can work in low-resource settings. The SiMBiT field-effect sensing system will be fabricated by means of future mass-manufacturable, large-area compatible, scalable techniques such as printing and other direct-writing processes. 3D printing of a module is also foreseen. The SiMBiT prototype will demonstrate, for first time, a matrix of up to 96 bio-electronic sensors and a Si IC chip for the processing of all data coming from the matrix, multiplexing single-molecule detection. As the Si IC pins are limited the chip area is reduced and its cost minimized, enabling a single-use assay plate. SiMBiT will apply the multiplexing single molecule technology to the early detection of human pancreatic neoplasms in a well-defined clinical context, performing simultaneous analysis of genomic and protein markers with a minimal sample volume, reduced costs and reduced time-to-results. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsmedical and health sciencesclinical medicineoncologypancreatic cancer Keywords sensing bio-electronic array electrolyte-gated TFT printable organic electronics field-effect transistor sensors point-of-care clinical diagnostics single-molecule detection Programme(s) H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT) Main Programme Topic(s) ICT-07-2018 - Electronic Smart Systems (ESS) Call for proposal H2020-ICT-2018-20 See other projects for this call Sub call H2020-ICT-2018-2 Funding Scheme RIA - Research and Innovation action Coordinator CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE Net EU contribution € 390 750,00 Address VIA DELLA LASTRUCCIA 3 50019 Firenze Italy See on map Region Centro (IT) Toscana Firenze Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 390 750,00 Participants (9) Sort alphabetically Sort by Net EU contribution Expand all Collapse all HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Germany Net EU contribution € 415 765,00 Address UNIVERSITAETSSTRASSE 1 40225 Dusseldorf See on map Region Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 415 765,00 UNIVERSITA DEGLI STUDI DI BRESCIA Italy Net EU contribution € 391 221,25 Address PIAZZA MERCATO 15 25121 Brescia See on map Region Nord-Ovest Lombardia Brescia Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 391 221,25 ABO AKADEMI Finland Net EU contribution € 350 000,00 Address DOMKYRKOTORGET 3 20500 Abo See on map Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 350 000,00 FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Italy Net EU contribution € 352 500,00 Address VIA MOREGO 30 16163 Genova See on map Region Nord-Ovest Liguria Genova Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 352 500,00 TECHNISCHE UNIVERSITEIT EINDHOVEN Netherlands Net EU contribution € 389 998,75 Address GROENE LOPER 3 5612 AE Eindhoven See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 389 998,75 FLEXENABLE LIMITED Participation ended United Kingdom Net EU contribution € 302 092,14 Address 34 CAMBRIDGE SCIENCE PARK, MILTON ROAD CB4 0FX Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 302 092,14 MASMEC SPA Italy Net EU contribution € 262 500,00 Address VIA DELLE VIOLETTE 14 70026 MODUGNO See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Sud Puglia Bari Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 262 500,00 IN EXTENSO INNOVATION CROISSANCE France Net EU contribution € 112 500,00 Address ROUTE DES LUCIOLES 2000 THALES B SOPHIA ANTIPOLIS 06410 Biot See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Alpes-Maritimes Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 112 500,00 FLEXENABLE TECHNOLOGY LIMITED United Kingdom Net EU contribution € 53 311,61 Address 34 CAMBRIDGE SCIENCE PARK, MILTON R CB4 0FX CAMBRIDGE See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 53 311,61