Project description DEENESFRITPL Cultivating a united and functional research organ to advance disease model systems Animal research has provided invaluable insight into human health and disease, increasing basic understanding and aiding in development and testing of therapies before moving to human clinical trials. Numerous model systems have now been developed to evaluate and test hypotheses as an alternative to animal testing. Among the most promising are organoids, tiny self-organised 3D organ-specific tissues from cultured stem cells. They provide a window on how tissues and organs form and grow and act as a test bench for evaluating drugs and other therapies. REMODEL is streamlining the organoid development process targeting three critically important areas: infection, cancer and tissue regeneration. Success relies on and will strengthen a confluence of European expertise in organoid systems. Show the project objective Hide the project objective Objective REMODEL combines the existing local expertise in bioengineering, cancer and infectious diseases with partners at the frontline in developing organoid systems, manipulating them to fit specific purposes and validating their use as models, in order to build capacity to work with innovative model systems that can replace animal experiments and increase translational relevance. In doing so, REMODEL addresses a key issue in today’s biomedical research: how non-animal model systems can be developed to meet the needs for translationally relevant research in the era of precision and personalized medicine, whilst at the same time accounting for societal pressure to replace animal experiments. REMODEL will capacitate the coordinating institution, IBMC-i3S, through the establishment of organoid advanced in vitro models and their customization for the main areas of research (infection, cancer and tissue regeneration). REMODEL will contribute to raising the research profile of the institution and scientific skills of its staff developed through training schools and short-term scientific training periods as well as transferable skills training and mentoring of Early Stage researchers, but also through staff participation in international conferences presenting work within the REMODEL themes / framework. Organoids as experimental models are at the frontline of methodological development in biomedicine, and demonstrating competence in working with such models will place i3S in the spotlight in an international research context, and make the institution an attractive partner for future collaborations beyond the REMODEL network. On the European level, REMODEL represents an important initiative to bring together key partners in the development of innovative models to overcome the present fragmentation of European organoid research and move towards applications in animal replacement. Fields of science medical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesclinical medicineoncologymedical and health scienceshealth sciencespersonalized medicine Keywords 3Rs Replacement organoids cancer infection tissue regeneration translation research model experimental model model system validation Programme(s) H2020-EU.4.b. - Twinning of research institutions Main Programme Topic(s) WIDESPREAD-03-2018 - Twinning Call for proposal H2020-WIDESPREAD-2018-2020 See other projects for this call Sub call H2020-WIDESPREAD-2018-03 Funding Scheme CSA - Coordination and support action Coordinator INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC Net EU contribution € 313 021,25 Address RUA ALFREDO ALLEN 208 4200 135 Porto Portugal See on map Region Continente Norte Área Metropolitana do Porto Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 313 021,25 Participants (3) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITEIT UTRECHT Netherlands Net EU contribution € 190 250,00 Address HEIDELBERGLAAN 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 190 250,00 KOBENHAVNS UNIVERSITET Denmark Net EU contribution € 109 375,00 Address NORREGADE 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 109 375,00 JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Germany Net EU contribution € 187 001,25 Address SANDERRING 2 97070 Wuerzburg See on map Region Bayern Unterfranken Würzburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 187 001,25
