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Development of “smart” amplifiers of reactive oxygen species specific to aberrant polymorphonuclear neutrophils for treatment of inflammatory and autoimmune diseases, cancer and myeloablation.

Project description

Targeted amplification of reactive oxygen species could fight serious diseases

A diet rich in antioxidants could protect against a variety of pathologies from cancer and neurological disorders to cardiovascular disease. Antioxidants soak up free radicals among which are reactive oxygen species (ROS). ROS, as their name suggests, are unstable molecules containing oxygen that easily react with other molecules in a cell. Initially considered damaging agents, we now know they also play a key role in healthy cell processes. The key seems to be in the amount of time they are present and at what levels in specific cells. NeutroCure is developing ways to control the spatial and temporal amplification of ROS generation to effectively treat severe pathological conditions characterised by a dysfunction in ROS homeostasis.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
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Funding Scheme

RIA - Research and Innovation action

Coordinator

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Address
Schlossplatz 4
91054 Erlangen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 629 000

Participants (6)

UNIVERSITY OF SURREY
United Kingdom
EU contribution
€ 410 998,75
Address
Stag Hill
GU2 7XH Guildford
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 640 000
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
LVIVSKYI NATIONALNYI MEDYCHNYI UNIVERSYTET IMENI DANYLA HALYTSKOHO
Ukraine
EU contribution
€ 400 000
Address
69 Pekarska Street
79010 Lviv
Activity type
Higher or Secondary Education Establishments
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Spain
EU contribution
€ 400 000
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations
REDOXIS AB
Sweden
EU contribution
€ 400 000
Address
Medicon Village Scheelevagen 2
223 81 Lund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT GUSTAVE ROUSSY
France
EU contribution
€ 120 000
Address
Rue Camille Desmoulins 39
94805 Villejuif
Activity type
Research Organisations