Project description DEENESFRITPL Pouring value into plastic waste streams Plastics are an important material in our economy, but there are serious downsides for the environment and our health. Plastic adversely affects all ecosystems and microplastics are of particular concern to our health. Increasing plastic waste recycling is a top priority in Europe’s transition towards a circular economy. The EU-funded MIX-UP project is addressing the market needs for new sustainable routes to valorise plastics waste streams. As such, plastic mixtures with five of the top six fossil-based recalcitrant plastics (PP, PE, PUR, PET and PS) and biodegradable plastics such as PLA and PHA, will be used as feedstock for microbial transformations. Not only will this increase the recycling quota, it will add value to poorly recycled plastic waste streams. Show the project objective Hide the project objective Objective The continuing demand for plastic products, the lack of appropriate recycling and the ubiquitous pollution of the environment with plastic waste pose a global challenge. An ambitious vision and considerable efforts are required to change the traditional value chain of plastics to a sustainable one, based on biodegradable plastics.In MIX-UP, plastic mixtures with five of the top six fossil-based recalcitrant plastics (PP, PE, PUR, PET, and PS), along with upcoming biodegradable plastics such as PLA and PHA, will be used as feedstock for microbial transformations, thereby generating a workflow that increases the recycling quota and adds value to poorly recycled plastics waste streams. Successive controlled enzymatic and microbial degradation of mechanically pre-treated plastics waste will be combined with subsequent microbial conversion to value-added chemicals and polymers by mixed cultures. We will optimize known plastics-degrading enzymes for high specific binding capacities, stability, and catalytic efficacy towards a broad spectrum of plastics polymers under high salt and temperature conditions by integrated protein engineering, and also isolate novel enzymes with activities on recalcitrant polymers. MIX-UP will also optimize the production of enzymes and formulate enzyme cocktails tailored to specific waste streams. Implementation of these enzymes, both in vitro and in vivo, enables stable self-sustaining microbiomes to convert the released plastic monomers selectively into at least six value-added products, key building blocks, and biomass. Any remaining material recalcitrant to enzymatic activity will be recirculated into the process after a physico-chemical treatment.The Chinese-European MIX-UP is a multidisciplinary and industry-driven consortium that addresses the market need for novel sustainable routes to valorise plastics waste streams. MIX-UP realises a circular (bio)-economy and could be a viable alternative for mechanical and chemical recycling. Fields of science engineering and technologyenvironmental engineeringwaste managementwaste treatment processesrecyclingengineering and technologyindustrial biotechnologybiomaterialsbioplasticspolylactic acidnatural scienceschemical sciencespolymer sciencesengineering and technologyindustrial biotechnologybiomaterialsbioplasticspolyhydroxyalkanoatesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Keywords PHA polyhydroxyalkanoate synthetic biology plastic recycling plastic crisis metabolic engineering microbial consortia mixed plastics valorisation biobased plastic depolymerisation Programme(s) H2020-EU.2.1.4. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology Main Programme Topic(s) CE-BIOTEC-05-2019 - Microorganism communities for plastics bio-degradation (RIA) Call for proposal H2020-NMBP-TR-IND-2018-2020 See other projects for this call Sub call H2020-NMBP-BIO-CN-2019 Funding Scheme RIA - Research and Innovation action Coordinator RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Net EU contribution € 1 923 917,61 Address Templergraben 55 52062 Aachen Germany See on map Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 923 917,61 Participants (15) Sort alphabetically Sort by Net EU contribution Expand all Collapse all International partner Legal entity established in a non-associated third country that is not eligible for funding under Article 10 of the Regulation (EU) No 1290/2013 laying down the rules for participation and dissemination in Horizon 2020. NANJING UNIVERSITY OF TECHNOLOGY China Net EU contribution € 0,00 Address Xinmofan road 5 Nanjing See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 500 000,00 International partner Legal entity established in a non-associated third country that is not eligible for funding under Article 10 of the Regulation (EU) No 1290/2013 laying down the rules for participation and dissemination in Horizon 2020. BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY China Net EU contribution € 0,00 Address Bei san huan dong lu 15 chao yang qu 100029 Beijing See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 500 000,00 AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain Net EU contribution € 784 717,39 Address Calle serrano 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 784 717,39 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland Net EU contribution € 509 955,00 Address Belfield 4 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 009 955,00 International partner Legal entity established in a non-associated third country that is not eligible for funding under Article 10 of the Regulation (EU) No 1290/2013 laying down the rules for participation and dissemination in Horizon 2020. TSINGHUA UNIVERSITY China Net EU contribution € 0,00 Address Qing hua yuan 100084 Beijing See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 500 000,00 UNIVERSITAET GREIFSWALD Germany Net EU contribution € 720 638,75 Address Domstrasse 11 17489 Greifswald See on map Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 120 638,75 International partner Legal entity established in a non-associated third country that is not eligible for funding under Article 10 of the Regulation (EU) No 1290/2013 laying down the rules for participation and dissemination in Horizon 2020. Institute of Process Engineering, Chinese Academy of Sciences China Net EU contribution € 0,00 Address Zhongguancun north second street 1 100190 Beijing See on map Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 400 000,00 SOPREMA France Net EU contribution € 50 500,00 Address 15 rue saint nazaire 67100 Strasbourg See on map Region Grand Est Alsace Bas-Rhin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 50 500,00 FORSCHUNGSZENTRUM JULICH GMBH Germany Net EU contribution € 314 426,25 Address Wilhelm johnen strasse 52428 Julich See on map Region Nordrhein-Westfalen Köln Düren Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 314 426,25 BIOPLASTECH LTD Ireland Net EU contribution € 521 882,50 Address Cashel road unit 9 block c cashel business centre 12 Dublin See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ireland Eastern and Midland Dublin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 521 882,50 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 355 875,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 417 922,50 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. UNIVERSITE DE STRASBOURG France Net EU contribution € 62 047,50 Address Rue blaise pascal 4 67081 Strasbourg See on map Region Grand Est Alsace Bas-Rhin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 62 047,50 EVERWAVE GMBH Germany Net EU contribution € 62 625,00 Address Struverweg 116 52070 Aachen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 62 625,00 AB ENZYMES GMBH Germany Net EU contribution € 82 276,80 Address Feldbergstrasse 78 64293 Darmstadt See on map Region Hessen Darmstadt Darmstadt, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 158 750,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. ROAL OY Finland Net EU contribution € 76 473,20 Address Tykkimaentie 15 05200 Rajamaki See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 76 473,20