European Commission logo
français français
CORDIS - Résultats de la recherche de l’UE
CORDIS

Functional interaction between a prefrontal and a thalamic nucleus for the consolidation of spatial memories

Description du projet

Comprendre la consolidation de la mémoire

La transformation d’événements en mémoire à long terme, un processus appelé consolidation de la mémoire, implique la participation de nombreuses régions du cerveau. Des preuves récentes indiquent que l’interaction entre le noyau latérodorsal (LD) du thalamus et le cortex cingulaire antérieur (CCA) est fondamentale pour la consolidation de la mémoire. Les scientifiques du projet METHA, financé par l’UE, prévoient d’étudier le circuit LD-CCA et, notamment, la manière dont les neurones de ces régions traitent les informations acquises pendant la formation en vue de les consolider et de s’en souvenir plus tard. Les résultats permettront de mieux comprendre la mémoire et ses pathologies connexes, telles que le trouble de stress post-traumatique et la démence.

Objectif

Memory consolidation is the process by which memories are converted into a long-lasting form allowing its recall later in time. It has been shown that memory consolidation is supported by the coordinated activation of a network of brain regions. In this regard, the hippocampus-cortical communication has been largely studied. Recent evidences point to the thalamus as a key region mediating this dialogue. In particular, the Laterodorsal Nucleus of the Thalamus (LD) activity has been shown to be essential for remote memory recall. Moreover, the LD shows high anatomical and functional connectivity with the Anterior Cingulate Cortex (ACC) which is a key structure for consolidation and remote memory recall. These data suggest that this LD-ACC pathway may be crucial during memory consolidation. The LD is known to harbor Head Direction (HD) cells which are neurons that fire to specific orientations of the animal head. Therefore, we hypothesized that the activity of the LD-ACC circuit represents spatial information that is required for recall of contextual fear memory. The present project was designed to test this hypothesis using a multi-level approach, that is unique in the field. First, we will address the causal role of the LD-ACC pathway in the recall of fear memory, by modulating its activity using optogenetics. Then we will investigate how LD cells, and LD-ACC projecting cells, are processing acquired information during the training to consolidate and recall them at a remote time point by directly visualizing the activity of the LD during acquisition and recall of contextual conditioned fear. The expected results will have a significant impact in the memory and in the spatial navigation field, and are of key importance to better understand memory and related pathologies such as post-traumatic stress disorder and dementia.

Régime de financement

MSCA-IF-EF-ST - Standard EF

Coordinateur

ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS
Contribution nette de l'UE
€ 196 707,84
Adresse
RUE VAUQUELIN 10
75231 Paris
France

Voir sur la carte

Région
Ile-de-France Ile-de-France Paris
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
€ 196 707,84