Project description DEENESFRITPL Alkenes and CO2 for eco-friendly organocatalytic reactions Alkenes and CO2 can be used to develop asymmetric organocatalytic reactions for environmentally-friendly manufacturing of medicinally-important building blocks which are abundant in drug molecules and agrochemicals. This will be the aim of the EU-funded SusCat project, following an interdisciplinary approach that combines theory, experiment and cheminformatics. The project will perform advanced computational analysis and physical organic experiments to increase understanding of the molecular level. SusCat will connect organic synthesis, computational modelling and physical organic studies, providing a unique alternative to environmentally harming metal mediated synthesis and contributing to Europe 2020 strategy priorities for sustainable growth and resource efficiency. Show the project objective Hide the project objective Objective SusCat aims to develop asymmetric organocatalytic reactions using cheap, commonplace starting materials (alkenes and CO2) to achieve environmentally-friendly manufacturing of medicinally important building blocks, which are abundant in drug molecules and agrochemicals. An atom economical manufacturing of these value-added products will be realized avoiding the use of intrinsically toxic reagents and production of waste chemical byproducts. We will adopt an interdisciplinary approach by combining experiment, theory and cheminformatics. SusCat promises to open new vistas in organocatalytic unbiased olefin activation, a longstanding quest in organic synthesis. This approach will also pave the way for the use of CO2 as a C1 synthon under mild conditions, which will not only help to reduce the carbon footprint but also add to the understanding of how nature uses CO2 as a source of energy. Moreover, the state-of-the-art computational analysis and physical organic experiments will be performed to gain insights on the molecular level. A detailed cheminformatics-based approach will be adopted to build a predictive statistical model and understand the structure activity relationship between the catalyst and the substrate. SusCat will equip the Experienced Researcher with new knowledge and skills in theory and experimentation, thus broadening his scientific background and enhancing his prospects as an independent researcher. At the same time, the Action and the Host group will benefit from the advanced knowledge in chemical catalysis acquired by the researcher during his stay. Overall, this study will create a bridge among organic synthesis, computational modelling and physical organic studies, providing not only a unique alternative to environmentally deleterious metal-mediated synthesis, but also contributing towards achieving the Europe 2020 strategy priorities: sustainable growth and resource efficiency. Fields of science natural scienceschemical sciencescatalysisnatural sciencesmathematicsapplied mathematicsstatistics and probability Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2019 - Individual Fellowships Call for proposal H2020-MSCA-IF-2019 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG Net EU contribution € 162 806,40 Address KAISER WILHELM PLATZ 1 45470 Muelheim An Der Ruhr Germany See on map Region Nordrhein-Westfalen Düsseldorf Mülheim an der Ruhr Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 162 806,40