Objective
Project description of the work to be carried out in Pushchino (Russia): The proposed object of study is apolipoprotein A-I, its mutants and fragments as specified in the general description of the project. The Pushchino group, which has a long experience in conducting similar protein studies, would like to join the project and use the opportunity to work inside a team of leading European laboratories. The members of the Russian group are ready to cover the following aspects of the project. The thermodynamic parameters of protein folding and stability will be characterized by differential scanning calorimetry (DSC), isothermal titration calorimetry (IC) and by monitoring the temperature-induced changes of the optical parameters, such as circular dichroism and fluorescence. These studies will be carried out in tight collaboration with the Granada group, both in Granada and Pushchino, and will include the development of the DSC data analysis procedures and software by the members of the Russian team.
In addition the Pushchino group is planning to provide the facilities for expression and purification of the protein, its mutants and folded fragments to be used in thermodynamic studies, which ususally consume relatively large amounts of highly purified samples. The Pushchino group is also able to perform the kinetic studies of protein folding by denaturants using conventional stop-flow techniques. The group has four high-sensitivity scanning calorimeters of various types, an isothermal calorimeter and optical instruments. The large-scale protein purification facilities will be provided by the Institute of Protein Research to which the group belongs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
71110 IRAKLION
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.